34879-43-1

Upstream product

• 625-33-2 3-penten-2-one 
• 536-74-3 phenylacetylene 
• 1833-53-0 2-(Trimethylsilyloxy)propene 
• 76782-76-8 Diethyl-(1-methyl-3-phenyl-2-propinyl)phosphat 
• 3102-33-8 trans-3-penten-2-one 
• 591-50-4 iodobenzene 

Relevant academic research and scientific papers

Direct conjugate addition of alkynes with α,β-unsaturated carbonyl compounds catalyzed by NCN-pincer Ru complexes

NCN-pincer Ru-complexes containing bis(oxazolinyl)phenyl ligands serve as suitable catalysts in the direct conjugate additions of α,β- unsaturated carbonyl compounds, including ketones, esters, and amides, as well as vinylphosphonates, giving various β-alkynyl carbonyl and phosphonate compounds. A bis(oxazolinyl)phenyl (phebox)-Ru complex also catalyzes the asymmetric conjugate addition of an alkyne with a β-substituted, α,β-unsaturated ketone to produce a chiral β-alkynyl ketone. Copyright

Palladium-catalyzed conjugate addition of terminal alkynes to enones

A practical protocol for the hydroalkynylation of enones using Pd catalysis is reported. The reaction proceeds efficiently with a variety of alkynes as well as with several cyclic and acyclic enones, providing synthetically relevant β-alkynyl ketones in good to excellent yields.

Steric tuning of silylacetylenes and chiral phosphine ligands for rhodium-catalyzed asymmetric conjugate alkynylation of enones

Rhodium-catalyzed asymmetric conjugate alkynylation of α,β-unsaturated ketones giving β-alkynylketones took place in high yields with high enantioselectivity. The reaction was realized by use of (triisopropylsilyl)acetylene combined with (R)-DTBM-segphos as a chiral phosphine ligand, where the sterically bulky substituents on the silicon and phosphorus atoms suppress the alkyne dimerization. Copyright

Copper(II) triflate-catalyzed nucleophilic substitution of propargylic acetates with enoxysilanes. A straightforward synthetic route to polysubstituted furans

A novel and efficient procedure for the synthesis of γ-alkynyl ketones by the nucleophilic substitution of propargylic acetates with enoxysilanes in the presence of a catalytic amount of Copper(II) triflate, has been developed. The substitution reaction c

FeCl3-catalyzed nucleophilic substitution of propargylic acetates with enoxysilanes

(Chemical Equation Presented) An efficient FeCl3-catalyzed substitution reaction of propargylic acetates with enoxysilanes under mild conditions to afford corresponding γ-alkynyl ketones has been developed. The substitution reaction is followed

Ir-catalyzed substitution of propargylic-type esters with enoxysilanes

Propargylic-type acetates react readily with enoxysilanes in the presence of 1 mol % of [Ir(cod){P(OPh)3}2]OTf activated preliminarily with molecular H2 to give β-alkynyl ketones in high to excellent yields. Substitution a