34883-08-4

Upstream product

• 487-69-4 2,4-dihydroxy-6-methylbenzaldehyde 
• 74-88-4 methyl iodide 
• 7149-90-8 2,4-dimethoxy-6-methyl-benzaldehyde 
• 77-78-1 dimethyl sulfate 
• 3209-13-0 O-methylorcinol 
• 4179-19-5 1,3-dimethoxy-5-methylbenzene 
• 50-00-0 formaldehyd 

Downstream Products

• 872304-60-4 3,6-dihydroxy-4-methoxy-2-methyl-benzaldehyde 
• 59263-71-7 2-acetoxy-4-methoxy-6-methyl-benzaldehyde 
• 110451-94-0 2-(2,2-diethoxyethoxy)-4-methoxy-6-methylbenzaldehyde 
• 59342-30-2 2-Benzyloxy-4-methoxy-6-methyl-benzaldehyde 
• 60059-02-1 2-methyl-3,4,6-trimethoxybenzaldehyde 
• 855751-99-4 2-ethoxycarbonyloxy-4-methoxy-6-methyl-benzoic acid 
• 59311-42-1 4-Hydroxy-2-(2-hydroxy-4-methoxy-6-methyl-phenoxy)-6-methyl-benzoic acid 
• 59311-41-0 4-Benzyloxy-2-(2-benzyloxy-4-methoxy-6-methyl-phenoxy)-6-methyl-benzoic acid benzyl ester 
• 59311-40-9 2-Benzyloxy-4-methoxy-6-methyl-phenol 

Relevant academic research and scientific papers

1,4,2-Dioxazines or N-Acyl Isoxazolidines from Organoselenium-induced Cyclisation of O-Allyl Hydroxamic Acids

O-Allyl hydroxamic acids easily give rise to organoselenium-induced cyclisation reactions to afford phenylseleno-substituted 1,4,2-dioxazines or N-acyl isoxazolidines as the kinetically or thermodynamically controlled products, respectively.

PYRIMIDINE DERIVATIVES AS PGE2 RECEPTOR MODULATORS

The present invention relates to pyrimidine derivatives of formula (I) wherein (R1)n, R3, R4a, R4b, R5a, R5b and Ar1 are as described in the description and their use in the treatment of cancer by modulating an immune response comprising a reactivation of the immune system in the tumor. The invention further relates to novel benzofurane and benzothiophene derivatives of formula (II) and their use as pharmaceuticals, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4.

Directed Remote Lateral Metalation: Highly Substituted 2-Naphthols and BINOLs by In Situ Generation of a Directing Group

A general synthesis of highly substituted 2-naphthols based on a new carbanionic reaction sequence is demonstrated. The reaction exploits the dual nature of lithium bases consisting of consecutive ring opening of readily available coumarins with either LiNEt2 or LiNiPr2 into Z-cinnamamides, thus generating a directing group in situ and allowing, by conformational freedom, a lateral directed remote metalation for ring closure to give the aryl 2-naphthols in good to excellent yields. These transformations can be combined to provide a more efficient one-pot process. Mechanistic insight into the remote lateral metalation step, demonstrating the requirement of Z-cinnamamide, is described. Application of this methodology to the synthesis of highly substituted 3,3′-diaryl BINOL ligands is also reported.

Benzimidazole Derivatives

Novel compounds of the formula I (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R, Q, W,

Naturally Occuring Dibenzofurans. Part 2. The Synthesis of Schizopeltic Acid

The structure of schizopeltic acid as 1,7-dimethoxy-8-methoxycarbonyl 3,9-dimethyldibenzofuran-4-carboxylic acid (1) has been confirmed by rational synthesis. 6-Methoxy-4-methylbenzofuran-2-carbaldehyde (10), available from 3,5-dimethoxytoluene (4) in six