34884-05-4

Upstream product

• 71-43-2 benzene 
• 1443359-64-5 methyl 5-benzylthiophene-3-carboxylate 
• 34767-84-5 2-Benzoyl-4-chloromethylthiophene 
• 135-00-2 2-Benzoylthiophene 
• 5271-67-0 2-Thiophenecarbonyl chloride 
• 74387-53-4 4-Acetoxymethyl-2-benzoylthiophene 

Downstream Products

• 1443360-52-8 2-benzyl-4-((2-bromophenoxy)methyl)thiophene 
• 1443360-44-8 N-((5-benzylthiophen-3-yl)methyl)-N-(2-iodophenyl)-4-methylbenzenesulfonamide 
• 1443360-58-4 2-benzyl-4H-thieno[3,2-c]chromene 
• 1443360-48-2 2-benzyl-5-tosyl-4,5-dihydrothieno[3,2-c]quinoline 

Relevant academic research and scientific papers

A thioannulation approach to substituted thiophenes from morita-baylis-hillman acetates of acetylenic aldehydes

A new protocol has been developed for the synthesis of substituted thiophenes under mild and metal-free reaction conditions via the base-promoted thioannulation of Morita-Baylis-Hillman acetates of acetylenic aldehydes with potassium thioacetate involving a tandem allylic substitution/deacetylative 5-exo-dig-thiocycloisomerization. The obtained products provide an entry to 4H-thieno[3,2-c]chromene and thieno[3,2-c]dihydroquinoline.

REACTION OF AROMATIC AND HETEROAROMATIC COMPOUNDS BEARING ELECTRON-ACCEPTING SUBSTITUENTS. 25. SYNTHESIS OF (5-BENZYL-3-THIENYL)METHANOL FROM 2-BENZOYLTHIOPHENE

Under the action of paraformaldehyde and AlCl3, 2-benzoylthiophene has been converted into 2-benzoyl-4-chloromethylthiophene, which on treatment with anhydrous sodium acetate has given 4-acetoxymethyl-2-benzoylthiophene.The reduction and simultaneous saponification of the latter under the conditions of the Kizhner reaction has yielded (5-benzyl-3-thienyl)methanol.