34899-90-6Relevant articles and documents
METHODS OF PREPARING a,?-UNSATURATED OR a-HALO KETONES AND ALDEHYDES
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Paragraph 0116; 0117; 0130; 0131; 0138; 0139, (2017/07/14)
Copper(II) bromide mediated oxidation of acylated enol and use of the reaction in the synthesis of α,β-unsaturated or α-bromo ketones or aldehydes are disclosed. The method provides an efficient and practical process for manufacturing dehydrohedione (DHH) and many other versatile α,β-unsaturated or α-bromo ketones or aldehydes in large scales to avoid using precious metal compounds.
Stereocontrolled 1,3-phosphatyloxy and 1,3-halogen migration relay toward highly functionalized 1,3-dienes
Kazem Shiroodi, Roohollah,Dudnik, Alexander S.,Gevorgyan, Vladimir
supporting information; experimental part, p. 6928 - 6931 (2012/06/15)
A double migratory cascade reaction of α-halogen-substituted propargylic phosphates to produce highly functionalized 1,3-dienes has been developed. This transformation features 1,3-phosphatyloxy group migration followed by 1,3-shifts of bromine and chlorine as well as the unprecedented 1,3-migration of iodine. The reaction is stereodivergent: (Z)-1,3-dienes are formed in the presence of a copper catalyst, whereas gold-catalyzed reactions exhibit inverted stereoselectivity, producing the corresponding E products.
Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists
Palin, Ronald,Barn, David R.,Clark, John K.,Cottney, Jean E.,Cowley, Phillip M.,Crockatt, Marc,Evans, Louise,Feilden, Helen,Goodwin, Richard R.,Griekspoor, Frank,Grove, Simon J.A.,Houghton, Andrea K.,Jones, Philip S.,Morphy, Richard J.,Smith, Alasdair R.C.,Sundaram, Hardy,Vrolijk, David,Weston, Mark A.,Wishart, Grant,Wren, Paul
, p. 589 - 593 (2007/10/03)
A series of 3-phenoxypropyl piperidine analogues have been discovered as novel ORL1 receptor agonists. Structure-activity relationships have been explored around the 3-phenoxypropyl region with several potent and selective analogues identified.
