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Usage

Uses

Used in Pharmaceutical Industry:
2-HydroxyMethyl-5-trifluoroMethyl-phenol is used as an intermediate in the synthesis of various pharmaceuticals due to its versatile chemical properties. Its antioxidant and antifungal properties contribute to the development of medications with enhanced efficacy and safety profiles.
Used in Agrochemical Industry:
In the agrochemical sector, 2-HydroxyMethyl-5-trifluoroMethyl-phenol is utilized as an intermediate for the production of agrochemicals. Its properties make it suitable for the development of pesticides and other agricultural chemicals that can protect crops from diseases and pests.
Used in Personal Care and Cosmetics Industry:
2-HydroxyMethyl-5-trifluoroMethyl-phenol is used as an active ingredient in personal care products and cosmetics for its antioxidant and antifungal properties. It helps in maintaining the quality and extending the shelf life of these products while also providing skin-friendly benefits.
Used in Material Science:
This chemical compound is employed in the research and development of new materials. Its unique properties make it a promising candidate for the creation of innovative materials with improved performance characteristics.
Used in Medical Research:
2-HydroxyMethyl-5-trifluoroMethyl-phenol is utilized in medical research for its potential applications in the development of new therapeutic agents and diagnostic tools. Its antioxidant properties may contribute to the prevention and treatment of various diseases.
It is crucial to handle 2-HydroxyMethyl-5-trifluoroMethyl-phenol with care and adhere to safety protocols to minimize the risk of skin and eye irritation.

Upstream product

• 328-90-5 4-trifluoromethylsalicylic acid 

Downstream Products

• 58914-34-4 2-hydroxy-4-(trifluoromethyl)benzaldehyde 

Relevant academic research and scientific papers

Optical Control of CRAC Channels Using Photoswitchable Azopyrazoles

The Ca2+ release-activated Ca2+ (CRAC) channels control many Ca2+-modulated physiological processes in mammals. Hyperactivating CRAC channels are known to cause several human diseases, including Stormorken syndrome. Here, we show the design of azopyrazole-derived photoswitchable CRAC channel inhibitors (designated piCRACs), which enable optical inhibition of store-operated Ca2+ influx and downstream signaling. Moreover, piCRAC-1 has been applied in vivo to alleviate thrombocytopenia and hemorrhage in a zebrafish model of Stormorken syndrome in a light-dependent manner.

Asymmetric Retro-Claisen Reaction by Synergistic Chiral Primary Amine/Palladium Catalysis

We described herein a chiral primary amine/palladium catalyzed asymmetric retro-Claisen reaction of β-diketones with salicylic carbonates. A series of chiral α-alkylated ketones and macrolides were obtained with good yields and excellent enantioselectivities upon a sequence of decarboxylative benzylation, retro-Claisen cleavage, and enamine protonation. This strategy features broad substrate scope, mild conditions, as well as high atom economy with salicylic carbonates as the o-quinone methide precursors.

NOVEL SUBSTITUTED PYRIDO-PIPERAZINONE DERIVATIVES AS GAMMA SECRETASE MODULATORS

The present invention is concerned with novel substituted pyrido-piperazinone derivatives of Formula (I) wherein R1, R2, R3, R4, R5, L, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

NOVEL SUBSTITUTED PYRIDO-PIPERAZINONE DERIVATIVES AS GAMMA SECRETASE MODULATORS

The present invention is concerned with novel substituted pyrido-piperazinone derivatives of Formula (I) wherein R1, R2, R3, R4, R5, L, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

MODULATORS OF DOPAMINE NEUROTRANSMISSION

The present invention relates to novel1-(4H-1,3-benzodioxin-2-yl)methanamine derivatives, useful as modulators of dopamine neurotransmission, and more specifically asdopaminergic stabilizers. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA

The invention provides 1 -benzyl- 4 -piperidinamines of the general formula (I), processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are useful in the treatment of respiratory diseses such a

Heteroaryl and benzyl amide compounds

Compounds of formula I processes for their preparation, their use as pharmaceuticals and to pharmaceutical compositions comprising them.