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N-[3-(trifluoromethyl)phenyl]glycine, also known as trifluoromethylphenylglycine or TFMG, is an organic compound with the chemical formula C9H8F3NO2. It is a derivative of glycine, an amino acid, with a trifluoromethyl group attached to the phenyl ring. N-[3-(trifluoromethyl)phenyl]glycine is of interest in the field of medicinal chemistry, particularly in the development of drugs targeting the enzyme dihydroorotate dehydrogenase (DHODH), which plays a crucial role in the synthesis of pyrimidine nucleotides. TFMG and its analogs have been studied for their potential as inhibitors of DHODH, which could be useful in the treatment of certain diseases, such as cancer and autoimmune disorders. The trifluoromethyl group in TFMG enhances the compound's lipophilicity and metabolic stability, which are desirable properties for drug candidates.

349-81-5

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349-81-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 349-81-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,4 and 9 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 349-81:
(5*3)+(4*4)+(3*9)+(2*8)+(1*1)=75
75 % 10 = 5
So 349-81-5 is a valid CAS Registry Number.

349-81-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[3-(trifluoromethyl)anilino]acetic acid

1.2 Other means of identification

Product number -
Other names 2-{[3-(trifluoromethyl)phenyl]amino}acetic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:349-81-5 SDS

349-81-5Downstream Products

349-81-5Relevant academic research and scientific papers

Discovery and evolution of 12N-substituted aloperine derivatives as anti-SARS-CoV-2 agents through targeting late entry stage

Wang, Kun,Wu, Jia-Jing,Xin–Zhang,Zeng, Qing-Xuan,Zhang, Na,Huang, Wei-Jin,Tang, Sheng,Wang, Yan-Xiang,Kong, Wei-Jia,Wang, You-Chun,Li, Ying-Hong,Song, Dan-Qing

, (2021/08/03)

So far, there is still no specific drug against COVID-19. Taking compound 1 with anti-EBOV activity as the lead, fifty-four 12N-substituted aloperine derivatives were synthesized and evaluated for the anti-SARS-CoV-2 activities using pseudotyped virus model. Among them, 8a exhibited the most potential effects against both pseudotyped and authentic SARS-CoV-2, as well as SARS-CoV and MERS-CoV, indicating a broad-spectrum anti-coronavirus profile. The mechanism study disclosed that 8a might block a late stage of viral entry, mainly via inhibiting host cathepsin B activity rather than directly targeting cathepsin B protein. Also, 8a could significantly reduce the release of multiple inflammatory cytokines in a time- and dose-dependent manner, such as IL-6, IL-1β, IL-8 and MCP-1, the major contributors to cytokine storm. Therefore, 8a is a promising agent with the advantages of broad-spectrum anti-coronavirus and anti-cytokine effects, thus worthy of further investigation.

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