349098-14-2Relevant academic research and scientific papers
Synthesis, characterization, crystal structure and fluorescence property of tetramethyl 5,5′-(terephthaloylbis(azanediyl))-diisophthalate
Zhang, Qingfu,Geng, Aijing,Liu, Zhipeng,Shi, Yang,Sun, Dezhi
, p. 1124 - 1128 (2012)
An aroyl acylamide compound, tetramethyl 5,5′- (terephthaloylbis(azanediyl))-diisophthalate (1), has been prepared by nucleophilic substitution reaction of dimethyl 5-aminoisophthalate and terephthaloyl chloride, and characterized by elemental analysis, F
Metal-organic polyhedra containing 36 and 24 folds of amide groups for selective luminescent recognition of natural disaccharides
Jiao, Yang,Zhang, Jing,Zhang, Lejie,Lin, Zhihua,He, Cheng,Duan, Chunying
, p. 6022 - 6024 (2012/07/01)
An octa-nuclear bicoronal Ce-based triangular prism and tetra-nuclear molecular tetrahedron containing 36 and 24 folds amides within their main backbones were achieved and structurally characterized for the selective luminescent recognition of lactose and sucrose, respectively, over other related natural mono- and disaccharides.
Synthesis of analogues of Congo red and evaluation of their anti-prion activity
Sellarajah, Shane,Lekishvili, Tamuna,Bowring, Claire,Thompsett, Andrew R.,Rudyk, Helene,Birkett, Christopher R.,Brown, David R.,Gilbert, Ian H.
, p. 5515 - 5534 (2007/10/03)
No cure as of yet exists for any of the transmissible spongiform encephalopathies. In this paper, we describe the synthesis of analogues of Congo red and evaluation against a cellular model of infection, the SMB (scrapie mouse brain) persistently infected cell line, for their ability to inhibit the infectivity of the abnormal form of prion protein (PrP-res). The compounds have also been tested for their ability to inhibit the polymerization of PrP C by PrP-res. A number of analogues showed inhibition of PrP-res infectivity at nanomolar concentrations. Several analogues show promise; the most active compound, 2a, inhibits the formation of PrP-res in SMB cells with an EC50 of 25-50 nM.
