349102-18-7Relevant academic research and scientific papers
Stereocontrolled preparation of diversely trifunctionalized cyclobutanes
Aitken, David J.,Boddaert, Thomas,Chang, Zong,Guillot, Régis
, (2019)
The expedient and stereoselective syntheses of small libraries of trifunctionalized cyclobutane scaffolds bearing an acid, an amine, and a third functional group are described. Starting from a single precursor, the readily available protected derivative of all-cis-2-amino-3-hydroxycyclobutane-1-carboxylic acid, cis-trans stereoisomers are obtained following an SN2-type reaction, while all-trans stereoisomers are obtained using the same strategy preceded by a C1 epimerization reaction.
