34911-51-8

Basic information

• Product Name: 2-Bromo-3'-chloropropiophenone
• Synonyms: 2-BROMO-1-(3-CHLOROPHENYL)-1-PROPANONE;2-BROMO-1-(3-CHLOROPHENYL)PROPAN-1-ONE;2-BROMO-3'-CHLOROPROPIOPHENONE;3'-CHLORO-2-BROMOPROPIOPHENONE;3'-Chloro-α-bromopropiophenone;α-BroMo-3-chloropropiophenone;Bupropion 2-BroMo IMpurity;1-Propanone,2-broMo-1-(3-chlorophenyl)-
• CAS NO: 34911-51-8
• Molecular Formula: C₉H₈BrClO
• Molecular Weight: 247.52
• EINECS: 252-282-1
• Product Categories: Aromatics
• Mol File: 34911-51-8.mol
• Article Data: 39

Chemical Properties

• Boiling Point: 295 °C at 760 mmHg
• Flash Point: 132.2 °C
• Appearance: Colorless to pale yellow/Liquid
• Density: 1.532
• Refractive Index: 1.5770
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility: Soluble in acetonitrile, chloroform, dichloromethane and ethyl a
• CAS DataBase Reference: 2-Bromo-3'-chloropropiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-3'-chloropropiophenone(34911-51-8)
• EPA Substance Registry System: 2-Bromo-3'-chloropropiophenone(34911-51-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 34911-51-8(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Oil

Uses

It used as an important intermediate for raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.

Upstream product

• 108-90-7 chlorobenzene 
• 34841-35-5 3'-chloro-propiophenone 
• 26293-11-8 β-methyl-3-chlorostyrene 
• 17408-16-1 3'-nitropropiophenone 
• 93-55-0 1-phenyl-propan-1-one 
• 1197-05-3 1-(3-amino-phenyl)-propan-1-one 

Downstream Products

• 94026-07-0 2-<3-Chlor-anilino>-1-<3-chlor-phenyl>-propanon-(1) 
• 233600-52-7 (2SR,3SR)-hydroxybupropion 
• 23551-87-3 2-amino-2-methyl-propan-1-ol; hydrobromide 
• 31677-93-7 BUPROPION HYDROCHLORIDE 
• 1612226-20-6 1-(3-chlorophenyl)-2-((trifluoromethyl)thio)propan-1-one 
• 1216893-18-3 [²H₆]hydroxybupropion 
• 1607439-32-6 2-(methylamino)-1-(3’-chlorophenyl)-1-oxopropane hydrochloride 
• 1049677-59-9 3‐chloromethcathinone 

Relevant articles and documents

Microwave-assisted Vilsmeier-Haack synthesis of Pyrazole-4-carbaldehydes

The synthesis of 4-formylpyrazoles using Vilsmeier-Haack reagent is a common protocol in pyrazole chemistry. An efficient microwave-assisted synthesis of 4-formylpyrazoles by employing Vilsmeier-Haack reagent (OPC-VH) derived from phthaloyl dichloride/dimethylformamide has been described. This method offers the advantages of operational simplicity, avoiding the use of POCl3 as toxic reagents and reuse of the by-product in the preparation of phthaloyl dichloride.

A Method for the Catalytic Enantioselective Synthesis of Chiral α-Azido and α-Amino Ketones from Racemic α-Bromo Ketones, and Its Generalization to the Formation of Bonds to C, O, and S

A new and practical method has been developed for the transformation of racemic α-bromo ketones to chiral α-azido and α-amino ketones with high enantioselectivity using phase transfer, ion-pair mediated reactions with a recoverable chiral quaternary salt (10 mol %) as catalyst in fluorobenzene-water. The process has been generalized to a variety of other attachments including of C, O, S, and NHR.

Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server

The power of the Cloud has been harnessed for pharmaceutical compound production with remote servers based in Tokyo, Japan being left to autonomously find optimal synthesis conditions for three active pharmaceutical ingredients (APIs) in laboratories in Cambridge, UK. A researcher located in Los Angeles, USA controlled the entire process via an internet connection. The constituent synthetic steps for Tramadol, Lidocaine, and Bupropion were thus optimized with minimal intervention from operators within hours, yielding conditions satisfying customizable evaluation functions for all examples.