349132-95-2

Usage

Explanation

This is the chemical name of the compound, which describes its structure and components.

Explanation

The compound is artificially created in a laboratory, rather than being derived directly from natural sources.

Explanation

The compound has potential uses in the pharmaceutical industry, possibly as a drug or in drug development processes.

Explanation

The core structure of the compound is a benzamide molecule, which is a type of aromatic amide.

Explanation

These two functional groups are attached to the benzamide molecule, giving the compound its unique properties and potential biological activity.

Explanation

The compound may exhibit biological activity due to its structural features, but further research is needed to confirm and understand this activity.

Explanation

The compound could potentially be used in medical research to study its properties or in drug development processes to create new pharmaceuticals.

Explanation

More research is required to fully understand the properties and potential applications of 2-(acetyloxy)-N-(6-nitro-2-benzothiazolyl)-Benzamide.

Type

Synthetic chemical compound

Potential applications

Pharmaceutical

Structure

Benzamide molecule

Attached groups

Acetyloxy group, 6-nitro-2-benzothiazolyl group

Biological activity

Potential

Use in research

Medical research or drug development

Further research needed

Properties and potential uses

Upstream product

• 301165-41-3 2-hydroxy-N-(6-nitro-1,3-benzothiazol-2-yl)benzamide 
• 108-24-7 acetic anhydride 
• 69-72-7 salicylic acid 
• 100-01-6 4-nitro-aniline 
• 6285-57-0 2-amino-6-nitrobenzothiazole 
• 5538-51-2 O-acetylsalicyloyl chloride 

Downstream Products

• 301165-41-3 2-hydroxy-N-(6-nitro-1,3-benzothiazol-2-yl)benzamide 

Relevant academic research and scientific papers

Nitazoxanide analogues as antimicrobial agents against nosocomial pathogens

Background: The frequent use of antibacterial agents and the exposure of the patients to lifesaving intervention processes are consistently associated with the increased chance of nosocomial infections and the emergence of multidrug resistant microorganisms in the hospital environment. Thus, new antimicrobial agents are of unmet need to treat the severe nosocomial infections caused by these putative pathogens resistant to currently available agents. Method: Design, synthesis, and biological evaluation of analogues of nitazoxanide (NTZ), an FDA approved thiazolide antiparasitic, as new antimicrobial agents against nosocomial pathogens were described. The NTZ analogues were rationally explored on the basis of either increasing the electronic resonance effects at the nitrothiazolide moiety or improving the anionic form of the whole NTZ structure. Results: The MICs and MBCs values of these NTZ analogues against prevalent nosocomial pathogens were measured. The benzologous analogues 3a and 4a and p-chlorobenzenesulfonamides 8d and 9d exhibited tremendous antimicrobial activities, which were 100- To 2000-fold more potent than NTZ and ciprofloxacin. Conclusion: The results demonstrated that delicate manipulation of the NTZ core structure could lead to promising antimicrobial agents against the nosocomial pathogens.

Synthesis of benzologues of Nitazoxanide and Tizoxanide: A comparative study of their in vitro broad-spectrum antiprotozoal activity

We have synthesized two new benzologues of Nitazoxanide (NIT) and Tizoxanide (TIZ), using a short synthetic route. Both compounds were tested in vitro against six protozoa (Giardia intestinalis, Trichomonas vaginalis, Entamoeba histolytica, Plasmodium berghei, Leishmania mexicana and Trypanosoma cruzi). Compound 1 (benzologue of NIT) showed broad antiprotozoal effect against all parasites tested, showing IC50's 5μM. This compound was five-times more active than NIT, and 18-times more potent than metronidazole against G. intestinalis. It was 10-times more active than pentamidine against L. mexicana, and it was sevenfold more potent than benznidazole versus T. cruzi. This compound could be considered as a new broad spectrum antiprotozoal agent.