34916-93-3Relevant academic research and scientific papers
A novel system for the synthesis of nitriles from aldehydes using aqueous ammonia and sodium dichloroiodate
Telvekar, Vikas N.,Patel, Kavit N.,Kundaikar, Harish S.,Chaudhari, Hemchandra K.
, p. 2213 - 2215 (2008)
A simple and mild method for the conversion of varieties of aldehydes to the corresponding nitriles using aqueous ammonia and aqueous sodium dichloroiodate reagent at room temperature is discussed. Advantages of this system are short reaction time, easy work-up and moderate to good yields.
Asymmetric synthesis of α-substituted nitriles and cyanohydrins by oxidative cleavage of chiral aldehyde hydrazones with magnesium monoperoxyphthalate
Enders, Dieter,Plant, Andrew,Backhaus, Dirk,Reinhold, Ulrich
, p. 10699 - 10714 (2007/10/02)
Optically active α- and α,β-substituted aldehyde hydrazones 2, 4, and 7, which are readily available by assymmetric alkylation, Michael addition or [2,3]-Wittig rearrangement of chiral hydrazones can be transformed into nitriles 3 and 5 or cyanohydrins 8 by MMPP mediated oxidation, respectively. This synthetic sequence offers a C-C connective entry into optically active functionalised nitriles with good overall yields (30-75%) together with high diastereo- and enantioselectivities (de = 76 - ≥ 96%, ee ≥ 72 - ≥ 97%).
