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H-88, also known as KN-93, is a selective inhibitor of calmodulin-dependent protein kinase II (CaMKII). It is characterized by its ability to block the autophosphorylation of CaMKII, which is essential for the activation of this enzyme. H-88 has been extensively utilized in research to explore the role of CaMKII in diverse cellular processes such as signal transduction, gene expression, and synaptic plasticity. Moreover, it has demonstrated potential therapeutic benefits in preclinical studies for conditions like heart failure, neurodegenerative diseases, and cancer, although further research is required to elucidate its precise mechanisms and potential side effects for clinical application.

34929-08-3

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34929-08-3 Usage

Uses

Used in Research Studies:
H-88 is used as a research tool for investigating the role of CaMKII in various cellular processes, including signal transduction, gene expression, and synaptic plasticity. It aids in understanding the underlying mechanisms of these processes and the potential therapeutic implications of modulating CaMKII activity.
Used in Pharmaceutical Development:
H-88 is used as a potential therapeutic agent in preclinical studies for conditions such as heart failure, neurodegenerative diseases, and cancer. Its ability to inhibit CaMKII activity suggests that it may have beneficial effects in treating these conditions by modulating the pathways involved in their progression.
Used in Drug Discovery:
H-88 serves as a lead compound in drug discovery efforts aimed at developing new treatments for various diseases. Its selectivity for CaMKII and potential therapeutic benefits make it a valuable starting point for designing more effective and targeted drugs.

Check Digit Verification of cas no

The CAS Registry Mumber 34929-08-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,9,2 and 9 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 34929-08:
(7*3)+(6*4)+(5*9)+(4*2)+(3*9)+(2*0)+(1*8)=133
133 % 10 = 3
So 34929-08-3 is a valid CAS Registry Number.
InChI:InChI=1/C17H13F3N2O3/c18-17(19,20)11-4-3-5-12(10-11)22-14-7-2-1-6-13(14)15(24)21(8-9-23)16(22)25/h1-7,10,23H,8-9H2

34929-08-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(2-hydroxyethyl)-1-[3-(trifluoromethyl)phenyl]quinazoline-2,4-dione

1.2 Other means of identification

Product number -
Other names 3-(2-hydroxy-ethyl)-1-(3-trifluoromethyl-phenyl)-1H-quinazoline-2,4-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:34929-08-3 SDS

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