349399-06-0Relevant academic research and scientific papers
Discovery of a potent and highly selective transforming growth factor β receptor-associated kinase 1 (TAK1) inhibitor by structure based drug design (SBDD)
Muraoka, Terushige,Ide, Mitsuaki,Morikami, Kenji,Irie, Machiko,Nakamura, Mitsuaki,Miura, Takaaki,Kamikawa, Takayuki,Nishihara, Masamichi,Kashiwagi, Hirotaka
supporting information, p. 4206 - 4217 (2016/08/23)
A novel thienopyrimidinone analog was discovered as a potent and highly selective TAK1 inhibitor using the SBDD approach. TAK1 plays a key role in inflammatory and immune signaling, so TAK1 is considered to be an attractive molecular target for the treatm
Therapeutically Active Thiazolo-Pyrimidine Derivatives
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Paragraph 0247; 0248, (2014/10/29)
A series of thiazolo[5,4-d]pyrimidine derivatives of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: (I) Q represents a group of formula (Qa), (Qb), (Qc), (Qd) or (Qe) are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.
THERAPEUTICALLY ACTIVE THIAZOLO-PYRIMIDINE DERIVATIVES
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Page/Page column 47, (2013/05/23)
A series of thiazolo[5,4-d]pyrimidine derivatives of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: (I) Q represents a group of formula (Qa), (Qb), (Qc), (Qd) or (Qe) are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.
COMPOUNDS AND THERAPEUTIC USES THEREOF
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Page/Page column 112, (2010/11/03)
The invention relates to compounds, pharmaceutical compositions, and uses thereof, including therapeutic uses thereof, such as methods useful for treating cancer.
Novel and potent 5-piperazinyl methyl- N1-aryl sulfonyl indole derivatives as 5-HT6 receptor ligands
Nirogi, Ramakrishna V. S.,Kothmirkar, Prabhakar,Kambhampati, Ramasastri,Konda, Jagadish Babu,Arepalli, Sobhanadri,Pamuleti, Narasimhareddy G.,Deshpande, Amol D.,Bandyala, Trinathreddy,Shinde, Anil K.,Dubey
scheme or table, p. 340 - 344 (2010/11/18)
The exclusive distribution of 5-HT6 receptors in the brain regions associated with learning and memory makes it an ideal target for cognitive disorders. A novel series of 5-piperazinyl methyl-N1-aryl sulfonyl indoles were designed and synthesized as 5-HT6R ligands. Most of the synthesized compounds are potent when tested by in vitro radioligand binding assay. The lead compound from the series does not have the CYP liabilities and is active in an animal model of cognition.
