349405-25-0Relevant academic research and scientific papers
Design, synthesis and biological evaluation of 1H-indazole derivatives as novel ASK1 inhibitors
Hou, Shaohua,Yang, Xiping,Yang, Yuejing,Tong, Yu,Chen, Quanwei,Wan, Boheng,Wei, Ran,Lu, Tao,Chen, Yadong,Hu, Qinghua
, (2021)
Apoptosis signal-regulating kinase 1 (ASK1, MAP3K5), a member of the mitogen-activated protein kinase (MAPK) signaling pathway, is involved in cell survival, differentiation, stress response, and apoptosis. ASK1 kinase inhibition has emerged as a promisin
Discovery and optimization of a novel series of potent mutant B-Raf V600E selective kinase inhibitors
Vasbinder, Melissa M.,Aquila, Brian,Augustin, Martin,Chen, Huawei,Cheung, Tony,Cook, Donald,Drew, Lisa,Fauber, Benjamin P.,Glossop, Steve,Grondine, Michael,Hennessy, Edward,Johannes, Jeffrey,Lee, Stephen,Lyne, Paul,M?rtl, Mario,Omer, Charles,Palakurthi, Sangeetha,Pontz, Timothy,Read, Jon,Sha, Li,Shen, Minhui,Steinbacher, Stefan,Wang, Haixia,Wu, Allan,Ye, Minwei
, p. 1996 - 2015 (2013/05/09)
B-Raf represents an attractive target for anticancer therapy and the development of small molecule B-Raf inhibitors has delivered new therapies for metastatic melanoma patients. We have discovered a novel class of small molecules that inhibit mutant B-Raf
PYRIDINYLQUINAZ0LINAMINE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS
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Page/Page column 73, (2010/11/30)
The invention relates to chemical compounds of the formula (I) or pharmaceutically acceptable salts thereof, which possess B-Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.
