34944-03-1

Upstream product

• 615-43-0 2-iodophenylamine 
• 108501-85-5 N-(2-iodophenyl)-2-methylacrylamide 
• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 74480-63-0 N-benzyl-2-methyl-N-phenylprop-2-enamide 
• 490035-95-5 N-benzyl-2-(prop-1-en-2-yl)benzen-amine 
• 151-50-8 potassium cyanide 
• 122128-46-5 N-benzyl-N-(2-iodophenyl)-2-methylacrylamide 
• 324738-55-8 benzyl(2-isopropenyl)carbamyl chloride 

Downstream Products

• 755029-51-7 8-benzyl-3a-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole 

Relevant academic research and scientific papers

Palladium catalysed cascade cyclisation - Cyanide ion capture

A range of δ- and ω-alkenyl aryl- and vinyl-halides undergo palladium catalysed cyclisation with subsequent transfer of cyanide ion in the presence of potassium cyanide (1.2 mol) and 10 mol % 18-crown-6.

Ni-Catalyzed Reductive Arylcyanation of Alkenes

We disclose a Ni-catalyzed reductive arylcyanation of alkene using environmentally benign and nontoxic organo cyanating reagent N-cyano-N-phenyl-p-toluenesulfonamide. This reaction provides a new method for the rapid synthesis of cyano-substituted oxindoles and isoquinoline-1,3-diones and features high functional group tolerance. In addition, an enantioselective version was developed for the construction of enantiomerically enriched 3-cyanomethyl oxindole. This method has also been applied to the synthesis of natural alkaloids (+)-esermethole and (+)-physostigmine.

Synthesis and cytotoxic activity of novel hexahydropyrrolo[2,3-b]indole imidazolium salts

A series of novel hexahydropyrrolo[2,3-b]indole-1H-imidazolium salts were synthesized and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the 5,6-dimethyl-benzimidazole ring, and substitution of the imidazolyl-3-posi

Intramolecular cyanoamidation of unsaturated cyanoformamides catalyzed by palladium: an efficient synthesis of multi-functionalized lactams

The Pd(0)-catalyzed intramolecular cyanoamidation of several unsaturated cyanoformamides with alkenyl, allenyl, and alkynyl groups was investigated. In the cases of alkynyl and 1,1-disubstituted alkenyl cyanoformamides, the Pd(0)-catalyzed C-CN activation and subsequent insertion reaction proceeded smoothly and gave the corresponding lactams bearing a cyano group at the β-position in good yields. The mechanism of the reaction was also discussed.