34944-03-1Relevant academic research and scientific papers
Palladium catalysed cascade cyclisation - Cyanide ion capture
Grigg,Santhakumar,Sridharan
, p. 3163 - 3164 (1993)
A range of δ- and ω-alkenyl aryl- and vinyl-halides undergo palladium catalysed cyclisation with subsequent transfer of cyanide ion in the presence of potassium cyanide (1.2 mol) and 10 mol % 18-crown-6.
Ni-Catalyzed Reductive Arylcyanation of Alkenes
Li, Hengxu,Chen, Jiachang,Dong, Jueqi,Kong, Wangqing
supporting information, p. 6466 - 6470 (2021/08/23)
We disclose a Ni-catalyzed reductive arylcyanation of alkene using environmentally benign and nontoxic organo cyanating reagent N-cyano-N-phenyl-p-toluenesulfonamide. This reaction provides a new method for the rapid synthesis of cyano-substituted oxindoles and isoquinoline-1,3-diones and features high functional group tolerance. In addition, an enantioselective version was developed for the construction of enantiomerically enriched 3-cyanomethyl oxindole. This method has also been applied to the synthesis of natural alkaloids (+)-esermethole and (+)-physostigmine.
Synthesis and cytotoxic activity of novel hexahydropyrrolo[2,3-b]indole imidazolium salts
Zhou, Yunjing,Duan, Kunyun,Zhu, Liang,Liu, Zhengfeng,Zhang, Chaobo,Yang, Lijuan,Li, Minyan,Zhang, Hongbin,Yang, Xiaodong
, p. 460 - 465 (2016/01/09)
A series of novel hexahydropyrrolo[2,3-b]indole-1H-imidazolium salts were synthesized and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the 5,6-dimethyl-benzimidazole ring, and substitution of the imidazolyl-3-posi
Intramolecular cyanoamidation of unsaturated cyanoformamides catalyzed by palladium: an efficient synthesis of multi-functionalized lactams
Kobayashi, Yusuke,Kamisaki, Haruhi,Takeda, Hiroshi,Yasui, Yoshizumi,Yanada, Reiko,Takemoto, Yoshiji
, p. 2978 - 2989 (2007/10/03)
The Pd(0)-catalyzed intramolecular cyanoamidation of several unsaturated cyanoformamides with alkenyl, allenyl, and alkynyl groups was investigated. In the cases of alkynyl and 1,1-disubstituted alkenyl cyanoformamides, the Pd(0)-catalyzed C-CN activation and subsequent insertion reaction proceeded smoothly and gave the corresponding lactams bearing a cyano group at the β-position in good yields. The mechanism of the reaction was also discussed.
