349493-40-9

Basic information

• Product Name: Ethanone, 1-(5-pyrimidinyl)-, oxime, (1E)- (9CI)
• Synonyms: Ethanone, 1-(5-pyrimidinyl)-, oxime, (1E)- (9CI)
• CAS NO: 349493-40-9
• Molecular Formula: C₆H₇N₃O
• Molecular Weight: 137.13928
• Product Categories: PYRIMIDINE
• Mol File: 349493-40-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 1-(5-pyrimidinyl)-, oxime, (1E)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(5-pyrimidinyl)-, oxime, (1E)- (9CI)(349493-40-9)
• EPA Substance Registry System: Ethanone, 1-(5-pyrimidinyl)-, oxime, (1E)- (9CI)(349493-40-9)

Safety Data

• Hazardous Substances Data: 349493-40-9(Hazardous Substances Data)

Upstream product

• 10325-70-9 1-(pyrimidin-5-yl)ethan-1-one 

Downstream Products

• 349493-49-8 1-pyrimidin-5-yl-ethanone O-(4-methyl-benzyl)-oxime 
• 349493-50-1 1-pyrimidin-5-yl-ethanone O-(4-chloro-benzyl)-oxime 
• 349493-48-7 1-pyrimidin-5-yl-ethanone O-benzyl-oxime 

Relevant articles and documents

Synthesis and muscarinic activity of 1,2,3,4-tetrahydropyrimidine derivatives

3-Methyl-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde O-substituted oximes 4 and 1-(3-methyl-1,2,3,4-tetrahydropyrimidin-5-yl)ethanone O-substituted oximes 9 have been prepared as bioisosteric congeners of arecoline which is a muscarinic agonist for treatment of Alzheimer's disease. Starting from pyrimidine-5-carbaldehyde 1, formation of the 3-methylpyrimidinium salt and subsequent reduction afforded 1,2,3,4-tetrahydropyrimidine derivatives which were converted into oxalate salts in the interest of purity and stability. Binding affinities of prepared compounds for the cloned human muscarinic M1 receptor (h-M1) were determined by radioligand binding assay using [3H]-N-methylscopolamine (NMS).