3495-27-0

Usage

Uses

Used in Pharmaceutical Industry:
(4R)-4,5-dihydroxy-2-oxopentanoic acid is used as a precursor in the synthesis of various pharmaceuticals and natural products due to its involvement in the biosynthesis of important molecules in the body.
Used in Research Studies:
(4R)-4,5-dihydroxy-2-oxopentanoic acid is used as a subject of interest in research studies for its potential antioxidant and anti-inflammatory properties, which could lead to the development of new treatments and therapies.

Upstream product

• 1427006-76-5 (R)-ethyl 3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-oxopropanoate 

Relevant academic research and scientific papers

Syntheses of 2-keto-3-deoxy-D-xylonate and 2-keto-3-deoxy-L-arabinonate as stereochemical probes for demonstrating the metabolic promiscuity of sulfolobus solfataricus towards D-xylose and L-arabinose

Practical syntheses of 2-keto-3-deoxy-D-xylonate (D-KDX) and 2-keto-3-deoxy-L-arabinonate (L-KDA) that rely on reaction of the anion of ethyl 2-[(tert-butyldimethylsilyl)oxy]-2-(dimethoxy phosphoryl) acetate with enantiopure glyceraldehyde acetonide, followed by global deprotection of the resultant O-silyl-enol esters, have been developed. This has enabled us to confirm that a 2-keto-3-deoxy-D-gluconate aldolase from the archaeon Sulfolobus solfataricus demonstrates good activity for catalysis of the retro-aldol cleavage of both these enantiomers to afford pyruvate and glycolaldehyde. The stereochemical promiscuity of this aldolase towards these enantiomeric aldol substrates confirms that this organism employs a metabolically promiscuous pathway to catabolise the C5-sugars D-xylose and L-arabinose.