34953-87-2

Usage

Uses

Used in Pharmaceutical Industry:
4-Pyrimidinemethanol, 2-chloro(9CI) is used as a key building block for the synthesis of various medications. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 4-Pyrimidinemethanol, 2-chloro(9CI) serves as a valuable intermediate for the preparation of a wide range of chemical compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Chemical Research:
4-Pyrimidinemethanol, 2-chloro(9CI) is also utilized in chemical research for studying the properties and reactions of pyrimidine-based compounds, contributing to the advancement of scientific knowledge in this area.
It is important to handle 4-Pyrimidinemethanol, 2-chloro(9CI) with care, as it may pose health and environmental risks if not used properly. Proper safety measures should be taken to minimize any potential hazards associated with its use.

Upstream product

• 149849-92-3 2‐chloropyrimidine‐4‐carboxylic acid 
• 149849-94-5 methyl 2,6-dichloropyrimidine-4-carboxylate 

Downstream Products

• 876314-63-5 2-chloro-5-(4-hydroxymethyl-pyrimidin-2-ylamino)-phenol 
• 944902-31-2 2-chloro-4-pyrimidinylmethyl chloride 
• 1580440-71-6 2-chloro-4-((4-fluorophenoxy)methyl)pyrimidine 
• 1580440-72-7 ethyl 4-fluoro-1-(4-((4-fluorophenoxy)methyl)pyrimidin-2-yl)piperidine-4-carboxylate 
• 181363-06-4 4-(bromomethyl)-2-chloropyrimidine 

Relevant academic research and scientific papers

MCL1 INHIBITORS AND USES THEREOF

The present disclosure provides compounds, such as compounds of Formula I, and compositions that are MCL1 inhibitors.

HETEROCYCLIC AMIDES AS KINASE INHIBITORS

Disclosed are compounds having the formula: wherein R1 and R2 are as defined herein, and methods of making and using the same.

PYRIDINEAMINE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS

The present disclosure describes pyridineamine compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer, immune disorders and other diseases. Formula (I).

NEW THIENOPYRIMIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R12, X, A and n are as defined in the description.

2,3-DISUBSTITUTED 1 -ACYL-4-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS

The present invention relates to novel compounds of formula (I), wherein R1 is C1-4alkyl; R2 is C1-4alkyl, C3-7cycloalkyl, -CH2CF3, -CH2OCH3 or heterocyclyl; R3 is C1-4alkyl, -CH2F, -CH2OH or -CH2O(O)CH3; R4 when present is as defined in claim 1; R5 when present is H, halo, hydroxy or C1-6alkoxy; A is -NH-, -O-, -S-, -SO-, -SO2-, -N(C1-4alkyl)- or -NC(O)(CH3)-; V is phenyl, heteroaromatic or pyridone any of which may be optionally substituted by 1, 2 or 3 substituents; W is CH or N; X is C or N; Y is C or N; and Z is CH or N; subject to the proviso that no more than 2 of W, X, Y and Z are N, pharmaceutical compositions containing such compounds and to their use as bromodomain inhibitors.