34956-85-9

Usage

Uses

Used in Pharmaceutical Production:
2-(5-bromopentyl)-2-ethyl-1,3-dioxolane is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the formation of complex organic molecules, which are essential in the development of new drugs.
Used as a Solvent in Industrial Processes:
In various industries, 2-(5-bromopentyl)-2-ethyl-1,3-dioxolane serves as a solvent due to its capacity to dissolve a wide range of substances, facilitating processes such as chemical reactions and material extraction.
Used in Organic Synthesis as a Reagent:
2-(5-bromopentyl)-2-ethyl-1,3-dioxolane is utilized as a reagent in organic synthesis, where it plays a crucial role in the formation of new chemical entities, contributing to the advancement of chemical research and development.
Used in Flavor and Fragrance Manufacturing:
2-(5-bromopentyl)-2-ethyl-1,3-dioxolane is employed in the creation of flavors and fragrances, capitalizing on its sweet, fruity scent to enhance the sensory properties of various consumer products.
Safety Considerations:
Given its flammability, 2-(5-bromopentyl)-2-ethyl-1,3-dioxolane should be handled with caution in well-ventilated areas to mitigate the risk of fire or explosion. The specific formulation and purity of the compound will determine its precise properties and applications, necessitating careful consideration during its use in different industries.

Upstream product

• 2146-62-5 8-bromo-octan-3-one 
• 107-21-1 ethylene glycol 
• 1940-18-7 1-ethylcyclohexanol 
• 6621-59-6 6-bromo-1-hexanenitrile 

Downstream Products

• 635680-16-9 2-amino-8-oxo-decanoic acid methyl ester 
• 891269-79-7 6-(2-Ethyl-1,3-dioxolan-2-yl)-1-(4-phenyl-2-thienyl)hexan-1-ol 
• 891269-98-0 6-(2-Ethyl-1,3-dioxolan-2-yl)-1-(2-phenyl-1,3-thiazol-5-yl)hexan-1-one 

Relevant academic research and scientific papers

Efficient Syntheses of Biologically Important (S)-2-Amino-8-oxodecanoic Acid (Aoda) and Homologues

The efficient and practical asymmetric syntheses of the biologically important (S)-2-amino-8-oxodecanoic ester and its homologues have been achieved employing the Schoellkopf chiral auxiliary. Carbon-carbon bond formation between the appropriate alkyl bromide and the LDA generated anion of the Schoellkopf auxiliary, followed by hydrolysis provided the desired methyl ester of a long-chained keto amino acid in high yield with high selectivity.

Design, synthesis, biological evaluation, and structural characterization of potent mistone deacarylase inhibitors based on cyclic α/β- tetrapeptide architectures

Histone deacetylases (HDACs) are a family of enzymes found in bacteria, fungi, plants, and animals that profoundly affect cellular function by catalyzing the removal of acetyl groups from ε-N-acetylated lysine residues of various protein substrates including histones, transcription factors, α-tubulin, and nuclear importers. Although the precise roles of HDAC isoforms in cellular function are not yet completely understood, inhibition of HDAC activity has emerged as a promising approach forreversing the aberrant epigenetic states associated with cancer and oth er chronic diseases. Potent new isoform-selective HDAC inhibitors would therefore help expand our understanding of the HDAC enzymes and represent attractive lead compounds for drug design, especially if combined withhigh-resolution structural analyses of such inhibitors to shed light on the three-dimensional pharmacophoric features necessary for the future design of more potent and selective compounds. Here we present structura l and functional analyses of a series of β acid-containing HDAC inhibitors inspired by cyclic tetrapeptide natural products. To survey a diverse ensemble of pharmacophoric configurations, we systematically varied the position of the β-amino acid, amino acid chirality, functionalization of the Zn2+-coordinating amino acid side chain, and alkylation of the backbone amide nitrogen atoms around the macrocycle. In many cases, the compounds were a single conformation in solution and exhibited potent activities against a number of HDAC isoforms as well as effective antiproliferative and cytotoxic activities against human tumorcells. High-resolution NMR solution structures were determined for a se lection of the inhibitors, providing a useful means of correlating detailed structural information with potency. The structure-based approach described here is expected to furnish valuable insights toward the future design of more selective HDAC inhibitors.

Ring-closing metathesis in the synthesis of biologically active peptidomimetics of apicidin A

Syntheses of novel 16-membered macrocyclic peptidomimetics are reported, which employ iterative peptide coupling followed by high yielding ring-closing metathesis (RCM) as the key cyclization step. The target macrocyclic compounds include examples contain