349586-22-7Relevant academic research and scientific papers
A new approach to β-functional phospholes. Application to the synthesis of a β-CH2-CH2-bridged diphosphole disulphide
Deschamps, Bernard,Buzin, Fran?ois-Xavier,Avarvari, Adina,Nief, Fran?ois,Mathey, Fran?ois
, p. 105 - 109 (2007/10/03)
Protection of both the dienic system and the lone pair of phosphorus of 1-phenyl-3,4-dimethylphosphole by complexation with iron carbonyl groups allow the regiospecific deprotonation of one β-methyl substituent by lithium diisopropylamide (LDA). The resulting anion exhibits versatile reactivity towards various electrophiles and can even undergo oxidative coupling with CuCl2, thus providing an entry into the unprecedented β-β′-bridged biphosphole system. Finally, the protecting iron carbonyl moieties can be cleanly removed in a two-step procedure involving reaction with sulphur and cerium ammonium nitrate (CAN).
