3496-32-0

Upstream product

• 2912-62-1 α-chlorophenylacetyl chloride 
• 3282-32-4 2-diazo-acetophenone 
• 3101-08-4 phenylcarbene 
• 201230-82-2 carbon monoxide 
• 79289-08-0 benzophenone α-chlorophenylacetylhydrazone 
• 908094-04-2 phenyldiazomethane 
• 4663-28-9 Benzoylketene 
• 103-80-0 phenylacetyl chloride 
• 104170-24-3 m-hydroxyethynyl benzene 
• 16141-49-4 trans-1,3,4-triphenyl-2-azetidinone 
• 1223-44-5 4-nitrophenyl 2-phenylacetate 
• 88043-32-7 Phenyl-acetic acid 2,4-dinitro-phenyl ester 
• 262-24-8 phenoxatellurine 
• 182752-94-9 3-oxo-4-phenyl-2-phenylhydrazonobutanenitrile 

Downstream Products

• 621-06-7 2,N-diphenylacetamide 
• 81040-10-0 (Z)-3-Phenyl-2-(trimethylsilyloxy)-2-propennitril 
• 61044-90-4 2-thiomethyl-5-phenyl-6-pyrimidone 
• 108228-39-3 2,3,5-Triphenyl-5,6-dihydro-4(3H)-pyrimidinone 
• 108228-40-6 2,5-diphenyl-1-p-tolyl-1,6-dihydropyrimidin-6-one 
• 108228-41-7 1-p-chlorophenyl-2,5-diphenyl-1,6-dihydropyrimidin-6-one 
• 108228-42-8 1-p-bromophenyl-2,5-diphenyl-1,6-dihydropyrimidin-6-one 
• 107855-52-7 4,6-Dimethyl-7-phenyl-2-thioxo-1,3-diaza-bicyclo[4.2.0]oct-3-en-8-one 
• 99234-06-7 (Z)-15-Phenyl-1,13-diaza-bicyclo[12.2.0]hexadec-13-en-16-one 
• 105625-81-8 2-Phenyl-3-[(E)-(3-phenyl-acryloyl)]-5-[1-phenyl-meth-(E)-ylidene]-3,5-dihydro-imidazol-4-one 
• 105625-85-2 5-[1-(4-Hydroxy-phenyl)-meth-(E)-ylidene]-2-phenyl-3-[(E)-(3-phenyl-acryloyl)]-3,5-dihydro-imidazol-4-one 
• 105625-83-0 5-[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-2-phenyl-3-[(E)-(3-phenyl-acryloyl)]-3,5-dihydro-imidazol-4-one 
• 103-82-2 phenylacetic acid 
• 889361-31-3 (3R,4S)-1,3,4-triphenyl-2-azetidinone 

Relevant academic research and scientific papers

A study of the vacuum pyrolysis of para-substituted diazoacetophenones with He(I) ultraviolet photoelectron spectroscopy

An ultraviolet photoelectron (PE) spectrometer apparatus that utilizes a tuneable 50 W CW CO2 laser as a directed heat source was used to study the vacuum pyrolysis of diazoacetophenone (1a) and its p-methyl, p-methoxy, p- chloro, and p-nitro a

A copper-catalyzed diastereoselective O-transfer reaction of: N -vinyl-α,β-unsaturated nitrones with ketenes into γ-lactones through [5 + 2] cycloaddition and N-O bond cleavage

A general protocol for the construction of novel densely functionalized γ-lactones was developed in good to excellent yields with high diastereoselectivity from easily available N-vinyl-α,β-unsaturated nitrones and ketenes. The reaction involves copper-catalyzed [5 + 2] cycloaddition, N-O bond cleavage, 6π electron cyclization, and aromatization to afford various γ-(pyridin-2-yl)lactones over four step transformations in a single flask. The present method features mild reaction conditions, high atom economy, high regio- and diastereoselectivity, diversity of γ-lactones, and a new application of the O-transfer reaction.

Elimination Reactions of Aryl Furylacetates Promoted by R2NH in MeCN: Effects of Base Solvent and β-Aryl Group on the Ketene-forming Transition State

Ketene-forming elimination from C4H3(O)CH2C(O)OC6H3-2-X-4-NO2 (1) promoted by R2NH in MeCN has been studied. The reactions produced elimination products and exhibited second-orde

Generation of Reactive Ketenes under Flow Conditions through Zinc-Mediated Dehalogenation

Herein, we describe the generation of highly reactive monoalkyl and phenyl ketenes by using a dehalogenation procedure under flow conditions. All ketenes were generated in good yields (determined by quenching with an appropriate aniline derivative) and showed high reactivity in the [2+2] cycloaddition with imines, resulting in the formation of a range of β-lactams at room temperature in less than 10 minutes. Furthermore, initial experiments were performed by using these reactive ketenes for the synthesis of β-lactams under flow conditions.

Green and reusable homogeneous oxidative system with ceric ammonium nitrate/[Imim-PEG1000-TEMPO] for efficient aerobic oxidation of alcohols and one-pot synthesis of benzimidazoles from alcohols under ambient conditions

An efficient and reusable catalytic system for aerobic oxidation of alcohols and one-pot synthesis of benzimidazoles from alcohols with ceric ammonium nitrate and PEG1000-ionic liquid-immobilized 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) is described. This system shows excellent activity and selectivity, affording the target products with good yields. Moreover, the catalytic system can be recycled and reused without significant loss of catalytic activity after seven runs.

Three in the spotlight: Photoinduced stereoselective synthesis of (Z)-acyloxyacrylamides through a multicomponent approach

We report a straightforward approach to synthesize 2-acyloxyacrylamides, which are useful synthons in organic synthesis. This involves a photoactivated multicomponent reaction, performed both in batch and under continuous flow conditions. This process affords the desired compounds in a stereoselective fashion from readily available starting materials in one step, without the aid of metal catalysis. This paper illustrates the preliminary work, the extensive experiments carried out to understand the limitations of the approach, and the optimization of the conditions for the synthesis of these particular captodative olefins.

Improvement of catalytic activity in selective oxidation of styrene with H2O2 over spinel Mg-Cu ferrite hollow spheres in water

Uniform spinel Mg-Cu ferrite hollow spheres were prepared using carbon spheres as templates. For comparison, solid Mg-Cu ferrite nanocrystals were also prepared by sol-gel auto-combustion, hydrothermal and coprecipitation methods. All the samples were characterized by Fourier transform infrared spectrophotometry (FT-IR), X-ray diffractometry (XRD), transmission electron microscopy (TEM) and N2 physisorption. The samples were found to be efficient catalysts for oxidation of styrene using hydrogen peroxide as oxidant. Especially, in the case of Mg0.5Cu0.5Fe2O 4 hollow spheres, obvious improvement on catalytic activity was observed, and 21.2% of styrene conversion and 75.2% of selectivity for benzaldehyde were obtained at 80 °C for 6 h reaction in water. The catalyst can be magnetically separated easily for reuse and no obvious loss of activity was observed when reused in six consecutive runs.

Identification of the rate-limiting step of the peroxygenase reactions catalyzed by the thermophilic cytochrome P450 from Sulfolobus tokodaii strain 7

Cytochrome P450 from the thermoacidophilic crenarchaeon Sulfolobus tokodaii strain 7 (P450st) is a thermophilic cytochrome P450 that shows high tolerance of harsh conditions and is capable of catalyzing some peroxygenase reactions. Here, we investigated t

Silver nitrate-catalyzed selective air oxidation of benzylic and allylic alcohols to corresponding aldehydes or ketones

The liquid phase selective air oxidation of benzylic and allylic alcohols to corresponding aldehydes or ketones has been achieved in high yields with catalytic amount of AgNO3 and in the presence of Na 2CO3. The liquid phase selective air oxidation of benzylic and allylic alcohols to corresponding aldehydes or ketones has been achieved in high yields with catalytic amount of AgNO3 and in the presence of Na2CO3.

Amination of phenylketene revisit. Substituent effect on reactivity

The asymmetric stretching frequencies of the ketene group of the m,p-substituted phenylketenes were found to be correlated with σ The substituent effects for the second-order rate constants of phenylketenes with various amines were not correlated linearly