34960-71-9Relevant academic research and scientific papers
Synthesis and purification method for minoxidil
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Paragraph 0014; 0015; 0016; 0021; 0022; 0023, (2017/09/18)
The invention discloses a synthesis and purification method for minoxidil, belonging to the field of chemical synthesis. The method comprises the following steps: with 2,4-diamino-6-chloropyridine as a raw material, carrying out a two-step reaction of low-temperature oxidation and condensation under the condition of alkali catalysis so as to obtain a crude minoxidil product, and carrying out purification through processes like polar solvent crystallization and active carbon decolorization so as to obtain a purified minoxidilum product. The purified minoxidilum product has a purity up to 99.7%; and the preparation method has simple and convenient operation and is applicable to industrial production.
Pyrimidine derivatives and process preparing the same
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, (2008/06/13)
A pyrimidine derivative of the formulae (Ia), (Ib) and (Ic), STR1 wherein R stands for an alkyl group group with 1 to 6 carbon atoms or an aryl group optionally substituted by halogen atom; and X stands for chlorine or bromine atom or an arylsulfonyloxy g
6-Amino-4-(substituted piperidino)-1,2-dihydro-1-hydroxy-2-iminopyrimidines
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, (2008/06/13)
6-Amino-1,2-dihydro-1-hydroxy-2-iminopyrimidines, their carboxyacylated counterparts, and the corresponding acid addition salts thereof are disclosed. These compounds, useful inter alia as antihypertensive agents, are substituted in the 4-position and optionally in the 5-position, the substituent in the 4-position being oxygen bearing secondary or tertiary amino moiety.
