349616-97-3Relevant academic research and scientific papers
Titanium(IV) isopropoxide as an efficient catalyst for direct amidation of nonactivated carboxylic acids
Lundberg, Helena,Tinnis, Fredrik,Adolfsson, Hans
, p. 2201 - 2204 (2012)
Secondary and tertiary amides are formed in high yields, in an efficient and environmentally benign titanium(IV) isopropoxide catalyzed direct amidation of carboxylic acids with primary and secondary amines. Georg Thieme Verlag Stuttgart ? New York.
Direct amide coupling of non-activated carboxylic acids and amines catalysed by zirconium(IV) chloride
Lundberg, Helena,Tinnis, Fredrik,Adolfsson, Hans
supporting information; experimental part, p. 3822 - 3826 (2012/05/20)
Amidst the green: A green, mild and effective protocol for the direct formation of secondary and tertiary amides from non-activated carboxylic acids and amines in good to excellent yields by employing ZrCl4 as the catalyst is presented (see scheme). The amide coupling protocol proved to be suitable for scaled up syntheses, and the mild reaction conditions conserve the enantiopurity of chiral starting materials. Copyright
