349636-73-3Relevant academic research and scientific papers
New oxadiazolidinedione derivatives as potent and selective human β3 agonists
Hu, Baihua,Malamas, Michael,Ellingboe, John,Largis, Elwood,Han, Stella,Mulvey, Ruth,Tillett, Jeff
, p. 981 - 984 (2007/10/03)
As part of our investigation into the development of potent and selective human β3 agonists, a series of thiazolidinedione analogues was prepared and evaluated for their biological activity on the human β3-adrenergic receptor. The oxadiazolidinedione derivative 17 was found to be the most potent and selective compound in this study, with an EC50 value of 0.02μM at the β3 receptor, 259-fold selectivity over the β1 receptor, and 745-fold selectivity over the β2 receptor.
