349649-07-6

Upstream product

• 73818-55-0 Bestmann ylide 
• 409061-78-5 (R)-3-(2-chloroacetyl)-4-phenyloxazolidin-2-one 

Downstream Products

• 749228-59-9 (4R)-3-((5S)-(2E)-methyloct-2-enoyl)-4-phenyloxazolidin-2-one 
• 658707-09-6 (4R)-3-((5S,7S)-(2E)-5,7-dimethyldec-2-enoyl)-4-phenyloxazolidin-2-one 
• 1126793-31-4 C₂₇H₂₅IN₂O₃ 
• 1041325-04-5 [4R,3(2E)]-3-(4-benzyloxy-2-butenoyl)-4-phenyl-2-oxazolidinone 
• 849592-43-4 (5''R)-(Z)-1-acetyl-6-bromo-2-methoxy-3-(2'-oxo-2'-(2''-oxo-5''-phenyl-3'',1''-oxazolidinyl)ethylidene)indoline 
• 349648-98-2 (R)-3-{(E)-3-[(1S,2S,3R,5R)-2-Allyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenylethynyl-3-trimethylsilanyloxy-8-oxa-bicyclo[3.2.1]oct-6-en-1-yl]-acryloyl}-4-phenyl-oxazolidin-2-one 

Relevant academic research and scientific papers

Intramolecular carbolithiation reactions for the synthesis of 2,4-disubstituted tetrahydro-quinolines: Evaluation of TMEDA and (-)-sparteine as ligands in the stereoselectivity

The preparation of 4-substituted 2-phenyltetrahydroquinolines from N-alkenylsubstituted 2-iodoanilines via intramolecular carbolithiation reactions has been investigated. The stereochemical outcome of the carbolithiation reactions depends on the nature of organolithium employed to perform the lithium-halogen exchange, the solvent, or the use of additives, for example, TMEDA or chiral bidentated ligands such as (-)-sparteine. Thus, the 2,4-disubstituted tetrahydroquinolines are obtained with moderate diastereoselectivities (up to 77:23) and with ee up to 94% when Weinreb amide derivatives are used (R) CONMe(OMe)).