349668-19-5Relevant academic research and scientific papers
Novel non-peptide ligands for the somatostatin sst3 receptor
Moinet, Christophe,Contour-Galcera, Marie-Odile,Poitout, Lydie,Morgan, Barry,Gordon, Tom,Roubert, Pierre,Thurieau, Christophe
, p. 991 - 995 (2001)
A series of imidazole derivatives has been prepared using high throughput parallel synthesis. Several compounds showed high affinity (Ki in 10-6-10-8M range) and selectivity at recombinant human somatostatin receptor subtype 3 (hsst3).
Identification of potent non-peptide somatostatin antagonists with sst3 selectivity
Poitout,Roubert,Contour-Galcéra,Moinet,Lannoy,Pommier,Plas,Bigg,Thurieau
, p. 2990 - 3000 (2007/10/03)
Using a solution-phase parallel synthesis strategy, a series of non-peptide somatostatin analogues were prepared, and their binding affinities to the five human somatostatin receptor subtypes (sst1-5) were determined. Imidazolyl derivatives 2 w
