34981-38-9

Basic information

• Product Name: 4-chlorotoluene-2-sulphonyl chloride
• Synonyms: 4-chlorotoluene-2-sulphonyl chloride;Benzenesulfonyl chloride, 5-chloro-2-methyl-;Einecs 252-306-0;5-chloro-2-Methylbenzenesulphonyl chloride;5-chloro-2-Methylbenzene-1-sulfonyl chloride;2-Chlorosulfonyl-4-chlorotoluene
• CAS NO: 34981-38-9
• Molecular Formula: C₇H₆Cl₂O₂S
• Molecular Weight: 225.09234
• EINECS: 252-306-0
• Mol File: 34981-38-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 314.9°Cat760mmHg
• Flash Point: 144.2°C
• Appearance: /
• Density: 1.458g/cm³
• Vapor Pressure: 0.000836mmHg at 25°C
• Refractive Index: 1.5697
• Storage Temp.: 2-8°C
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 4-chlorotoluene-2-sulphonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chlorotoluene-2-sulphonyl chloride(34981-38-9)
• EPA Substance Registry System: 4-chlorotoluene-2-sulphonyl chloride(34981-38-9)

Safety Data

• HazardClass: 8
• Hazardous Substances Data: 34981-38-9(Hazardous Substances Data)

Usage

Uses

5-Chloro-2-methylbenzenesulfonyl chloride is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.

InChI:InChI=1/C7H6Cl2O2S/c1-5-2-3-6(8)4-7(5)12(9,10)11/h2-4H,1H3

Upstream product

• 106-43-4 para-chlorotoluene 
• 95-79-4 5-chloro-2-methyl-benzenamine 

Downstream Products

• 26638-53-9 8-chloro-10,10-dioxo-11-methyl-5,11-dihydrodibenzo<1,2>thiazepin-5-one 
• 1353889-40-3 5-chloro-N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethylbenzenesulfonohydrazide 
• 46149-10-4 6-chloro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide 
• 51896-26-5 2-aminosulfonyl-4-chlorotoluene 
• 18858-06-5 5-chloro-2-methylthiophenol 
• 80568-07-6 ethyl 2-<(5-chloro-2-methylphenyl)thio>-5-nitrobenzoate 
• 874514-66-6 2-(5-chloro-2-methyl-phenylsulfanyl)-4-methyl-benzoic acid 
• 408351-36-0 2-(5-chloro-2-methyl-phenylsulfanyl)-benzoic acid 
• 479-50-5 lucanthone 
• 57450-55-2 1-chloro-4-methyl-9H-thioxanthen-9-one 

Relevant articles and documents

Quinazolinone Compound and Application Thereof

The present invention relates to a series of quinazolinone compounds and applications thereof as PI3Kα inhibitors. In particular, the present invention relates to a compound shown in formula (I) and a tautomer or pharmaceutically acceptable salt thereof.

Some new 1,2-benzothiazine derivatives with analgesic and anti-inflammatory activities

Twenty-three new 7-halo-4-hydroxy-2H(or alkyl)-N-(3-aralkyl-2-thio-l-hydantoinyl)-2H- 1,2-benzothiazine-3-carboxamide 1,1-dioxide derivatives were synthesized through the condensation of 7-halo-4-hydroxy-2H(or alkyl)-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxides with 1-amino-2-thio-3-aralkyl-imidazolidine-4-one. The analgesic and anti-inflammatory activities of the synthesized compounds were investigated by acetic acid-induced writhing syndrome and carrageenan rat paw edema tests. In analgesic activities most compounds exhibited higher activities than acetylsalicylic acid, but in antiinflammatory activities most compounds except compounds 24, 36, 39 showed lower activities than indometacin.