350-03-8 Usage
Identification
▼▲
CAS.No.:?
350-03-8?
FL.No.:?
14.039
FEMA.No.:?
3424
NAS.No.:?
3424
CoE.No.:?
2316
EINECS.No.:?
206-496-7?
JECFA.No.:?
1316
Description
A colorless liquid with sweet, nutty, popcorn-like aroma.
Regulatory Status
CoE: Used provisionally. Bev.: 2 ppm; Food: 3 ppm
FDA: n/a
FDA (other): n/a
JECFA: ADI: Acceptable. No safety concern at current levels of intake when used as a flavoring agent (2004).
Usage
Reported uses (ppm): (FEMA, 1994)
▼▲
Food Category?
Usual?
Max.?
Baked goods?
2
3
Frozen dairy?
1
2
Gelatins,puddings?
1
2
Nonalcoholic beverages?
1
2
Soft candy?
2
3
Natural occurrence
Reported found in roasted filberts, beer, brandy, coffee, malt and wheaten bread.
Chemical Properties
Different sources of media describe the Chemical Properties of 350-03-8 differently. You can refer to the following data:
1. clear colorless to yellow liquid
2. A colorless liquid with sweet, nutty, popcorn-like aroma
Occurrence
Reported found in roasted filberts, beer, brandy, coffee, malt and wheaten bread.
Uses
Different sources of media describe the Uses of 350-03-8 differently. You can refer to the following data:
1. 3-Acetylpyridine used as an intermediate for the synthesis of risedronate sodium, inhibitor of bone resorption. It is also used in perfumery.
2. Used in the fragrance industry and as an
intermediate in the synthesis of a number of clinical drugs,
including Imatinib, Mesylate, Metyrapone, Telithromycin, and
Ridogrel. An analog of nicotinamide that competes for incorporation
into NAD. It has been used to chemically lesion the inferior
olive nucleus, thereby eliminating climbing fibers within
the cerebellar cortex.
Preparation
Dry distillation of calcium nicotinate with calcium acetate.
Definition
It is a nicotinic acidantagonist.
Safety Profile
Poison by ingestion. Moderately toxic by intraperitoneal routeMutation data reported. A flammable liquid. When heated to decomposition emits toxic fumes of NOx,. See also KETONES
Purification Methods
It is purified by dissolving in HCl, extracting with Et2O to remove the possible impurity of nicotinic acid, basified with NaOH and extracted with Et2O. The dried extract is filtered, evaporated and the residual oil is distilled. If the NMR spectrum indicates further impurities, then convert it to the phenylhydrazone (m 137o, yellow needles from EtOH). This is hydrolysed with HCl [Engler & Kiby Chem Ber 22 597 1889], the phenylhydrazine HCl is removed by filtration, NaNO2 is added, the solution is basified with aqueous NaOH and extracted with Et2O as before and distilled at atmospheric pressure to give 3-acetylpyridine as a colourless oil. Purification can also be achieved by shaking with 50% aqueous KOH, extracting with Et2O, drying the extract and distilling it at atmospheric pressure or in vacuo. [Kloetzel & Chubb J Am Chem Soc 79 4226 1957.] The hydrochloride has m 180-181o (from MeOH/EtOH), the picrate has m 133.8-134.8o (from H2O), and the phenylhydrazone has m 137o (129-130o)(needles, from EtOH) [Webb & Webb J Am Chem Soc 71 2285 1949]. The ketoxime has m 112o (from EtOH or *C6H6). [Strong & McElvain J Am Chem Soc 55 816 1933, Kolloff & Hunter J Am Chem Soc 63 490 1941, Beilstein 21/7 V 394.]
Check Digit Verification of cas no
The CAS Registry Mumber 350-03-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,5 and 0 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 350-03:
(5*3)+(4*5)+(3*0)+(2*0)+(1*3)=38
38 % 10 = 8
So 350-03-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H7NO/c1-6(9)7-3-2-4-8-5-7/h2-5H,1H3
350-03-8Relevant articles and documents
-
Feuer
, p. 417,420 (1973)
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Micellar effects on kinetics and mechanism of Vilsmeier–Haack formylation and acetylation with Pyridines
Alyami, Bandar A.,Iqubal, S. M. Shakeel,Khan, Aejaz Abdullatif,Mohammed, Tasneem
, (2022/01/19)
An efficient preparation of Vilsmeier–Haack formylated and acetylated derivatives with pyridine and substituted pyridines has been developed by employing micelles as catalyst. Their kinetic study reveals a phenomenal rate enhancement in anionic SDS, cationic CTAB, and nonionic TX-100 micellar media. The Vilsmeier–Haack reaction follows second order kinetics. Piszkiewicz’s co-operativity model was used to interpret the results in micellar media. The observed activation parameters ΔH and ΔS values were calculated from Eyring’s plots. The main features of this study were easy process, mild reaction conditions and readily available reagents. Graphical abstract: [Figure not available: see fulltext.].
(±)-Camphor sulfonic acid assisted IBX based oxidation of 1° and 2° alcohols
Kumar, Kamlesh,Joshi, Penny,Rawat, Diwan S
, (2021/09/02)
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