350033-96-4Relevant academic research and scientific papers
Synthesis of β-aminovinyl ketones of the adamantane series
Makarova,Zemtsova,Moiseev
, p. 1469 - 1471 (2007/10/03)
1-(1-Adamantyl)-4-amino-3-buten-2-ones were synthesized by reaction of sodium 4-(1-adamantyl)-3-oxo-1-buten-1-olate with amine hydrochlorides. Sodium 3-R-3-oxo-1-propen-1-olates (R = methyl, phenyl, 4-chlorophenyl, 2-thienyl) reacted with 1-adamantylamine hydrochloride to afford 1-substituted 3-(1-adamantylamino)-2-propen-1-ones. Reactions of 1-adamantylamine with β-dicarbonyl compounds (acetylacetone and ethyl acetoacetate) in dry benzene gave 4-(1-adamantylamino)-3-penten-2-one and ethyl 3-(1-adamantyl-amino)-2-butenoate, respectively.
