35021-16-0Relevant articles and documents
Clicked AC regioisomer cationic cyclodextrins for enantioseparation
Zhou, Jie,Liu, Yun,Lu, Yingying,Tang, Jian,Tang, Weihua
, p. 54512 - 54516 (2015/02/05)
Novel AC regioisomer cationic cyclodextrins have been successfully prepared with azide/alkyne click chemistry. The clicked CDs were explored for the enantioseparation of acidic racemates in capillary electrophoresis.
Determination of enantiomeric purity of commercial 14C- and 3H- labeled L-α-amino acids
LeFevre, Joseph W.,Bonzagni, Neil J.,Chappell, Lara L.,Clement, David J.,Albro, Jeb R.,Lezynski, Denise M.
, p. 477 - 489 (2007/10/03)
The enantiomeric purity of twelve commercial 14C- and 3H-labeled L- α-amino acids was determined using reverse isotope dilution analysis. The technique utilized reversed-phase (RP) thin-layer chromatography (TLC) and beta-cyclodextrin (β-CD) in the mobile phase to separate D- and L-amino acids as their 5-dimethylamino-1-naphthalene sulfonyl (dansyl, DNS) derivatives. In all cases, the L-amino acid was contaminated with the D- isomer. This is the first report of the resolution of N-DNS-DL-tyrosine and N-(α)-DNS-DL-lysine using this methodology.
Direct resolution of optically active isomers on chiral packings containing ergoline skeletons. 5. Enantioseparation of amino acid derivatives
Messina,Girelli,Flieger,Sinibaldi,Sedmera,Cvak
, p. 1191 - 1196 (2007/10/03)
A new procedure for ergot alkaloid-based chiral stationary phase preparation is described. Synthesis is based on bonding the allyl derivative of terguride to mercaptopropylsilanized silica gel. The packing exhibits higher content of chiral selector, stability, reproducibility, and enantioselectivity toward amino acids compared to that previously studied. The chromatographic behavior of amino acids with different side chains and substituent groups is investigated in order to obtain a deeper insight into the enantiodiscriminative mechanism as well as to determine the limitations and strengths of terguride as a chiral selector for this class of compounds. A variety of factors, including mobile phase parameters such as pH, ionic strength, content and nature of organic modifier, and temperature, are examined. A new procedure for ergot alkaloid-based chiral stationary phase preparation is described. Synthesis is based on bonding the allyl derivative of terguride to mercaptopropylsilanized silica gel. The packing exhibits higher content of chiral selector, stability, reproducibility, and enantioselectivity toward amino acids compared to that previously studied. The chromatographic behavior of amino acids with different side chains and substituent groups is investigated in order to obtain a deeper insight into the enantiodiscriminative mechanism as well as to determine the limitations and strengths of terguride as a chiral selector for this class of compounds. A variety of factors, including mobile phase parameters such as pH, ionic strength, content and nature of organic modifier, and temperature, are examined.