35023-96-2Relevant academic research and scientific papers
Application of halide molten salts as novel reaction media for O-glycosidic bond formation
Kumar, Vineet,Talisman, Ian Jamie,Malhotra, Sanjay V.
supporting information; experimental part, p. 3377 - 3381 (2010/08/19)
In this study we have explored the application of halide molten salts as reaction media for O-glycosidic bond formation under basic conditions and mild heating. Eighteen different room-temperature ionic liquids and molten salts, representing four different classes of cations (i.e. imidazolium, pyridinium, pyrrolidinium and ammonium), were screened in the glycosidation reaction of p-nitrophenol with aceto-bromo-α-D-galactose. 1-Butyl-4-methylimidazolium chloride (BMIM·Cl) gave the best results and was applied in the reactions of other phenolic substrates to give the products with up to 80% yields. All the reactions were highly selective to give the β-anomers, and the molten salt BMIM·Cl could easily be reused with no apparent loss in activity.
