35025-95-7

Upstream product

• 70333-74-3 3',4'-dideoxy-1,2',3,6'-tetrakis-N-(trifluoroacetyl)neamine 
• 61066-03-3 1,2',3,6'-tetrakis-N-(trifluoroacetyl)neamine 
• 79628-26-5 3',4'-dideoxy-3'-eno-5,6-O-isopropylidene-1,2',3,6'-tetrakis-N-(trifluoroacetyl)neamine 
• 61066-04-4 5,6-isopropylidene-1,2',3,6'-tetrakis-N-(trifluoroacetyl)neamine 
• 61066-05-5 3',4',5,6-diisopropylidene-1,2',3,6'-tetrakis-N-(trifluoroacetyl)neamine 
• 79628-25-4 5,6-isopropylidene-3',4'-di-O-methanesulfonyl-1,2',3,6'-tetrakis-N-(trifluoroacetyl)neamine 
• 1086092-43-4 C₁₂H₁₈N₁₂O₄ 
• 3947-65-7 neomycin A 

Downstream Products

• 42801-36-5 1,3,2',6'-tetrakis-N-benzyloxycarbonylgentamine C_1a 
• 34493-98-6 dibecacin 
• 79384-36-4 O-3-acetamido-2,4,6-tri-O-benzyl-3-deoxy-α-D-glucopyranosyl-(1->6)-1,3,2',6'-tetrakis-N-benzyloxycarbonylgentamine C_1a 
• 1086092-43-4 C₁₂H₁₈N₁₂O₄ 
• 1141768-86-6 C₂₁H₄₀N₆O₉ 

Relevant academic research and scientific papers

MODULAR SYNTHESIS OF AMINOGLYCOSIDES

The present disclosure relates to novel methods for preparing antibacterial aminoglycoside compounds and the compounds used in such preparations.

Structure-toxicity relationship of aminoglycosides: Correlation of 2′-amine basicity with acute toxicity in pseudo-disaccharide scaffolds

A new pseudo-disaccharide NB23 with a 3′,4′-methylidene protection was designed and its properties were evaluated in comparison to other two structurally related pseudo-disaccharides. The basicity of the 2′-amine was found to be well correlated to acute toxicity data in mice: the increase in the basicity is associated with the toxicity increase. Based on these data, a new pseudo-trisaccharide NB45 was constructed. NB45 exhibited significant antibacterial activity while at the same time retained low acute toxicity.