35028-14-9

Upstream product

• 944268-64-8 1-(2,3-Dimethylphenyl)propan-1-ol 
• 74-96-4 ethyl bromide 
• 21900-46-9 2,3-dimethylbenzoyl chloride 
• 10108-64-2 cadmium(II) chloride 

Downstream Products

• 1001594-85-9 2,4-diphenyl-5-methyl-6-(2,3-dimethylphenyl)pyrylium tetrafluoroborate 
• 1001594-89-3 2-(4-methoxyphenyl)-4-phenyl-5-methyl-6-(2,3-dimethylphenyl)pyrylium tetrafluoroborate 

Relevant academic research and scientific papers

SUBSTITUTED IMIDAZOLES

This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.

Synthesis and activity of 2-methyl-3-aminopropiophenones as centrally acting muscle relaxants

Some novel 2-methyl-3-aminopropiophenones were synthesized and their centrally acting muscle relaxant activities were,evaluated for an inhibitory effect on the flexor reflex in rats. The structure-activity relationships are discussed. In this series 2-methyl-3-pyrrolidino-1-(4-trifluoromethylphenyl)-propan-1-one (28) showed significant centrally acting muscle relaxant activity. In addition, the activities of each enantiomer (28-(S) and (R)) were studied along with their acute toxicities. Compound 28-(R) was found to exhibit more potent activity and weaker acute toxicity than 28-(S). Accordingly, compound 28-(R) (NK433) is under development as a novel centrally acting muscle relaxant.

Derivatives of an aminoketone

A new class of aminoketone derivatives according to the formula: STR1 and certain propiophenone derivatives in particular, corresponding to the formula: STR2 having central muscle relaxant activity.