35031-53-9

Usage

General Description

2-5-dimethylbutyrophenone, also known as 2,5-dimethyl-1-phenyl-1-pentanone, is a chemical compound with the molecular formula C12H16O. It is a colorless liquid with a strong odor, commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 2-5-dimethylbutyrophenone is also used as a flavoring agent in the food industry and as a fragrance in the cosmetic industry. It is classified as a ketone, containing a carbonyl group bonded to two alkyl groups, and is considered to be relatively stable and non-reactive under normal conditions. However, it should be handled with care due to its potential to cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 106-42-3 para-xylene 
• 107-92-6 butyric acid 
• 141-75-3 butyryl chloride 

Downstream Products

• 1601-71-4 1,4-dimethyl-2-butylbenzene 
• 1453-06-1 4-(p-xylyl)butyric acid 

Relevant academic research and scientific papers

Friedel-Crafts acylation reaction using carboxylic acids as acylating agents

Dehydrative Friedel-Crafts acylation reaction of aromatic compounds with carboxylic acids as acylating agents was investigated in the presence of Lewis acid- or Br?nsted acid-catalyst. Various metal triflates and bis(trifluoromethanesulfonyl)amides showed catalytic activity at high temperature, among which Eu(NTf2)3 proved to be the most effective and efficiently catalyzed the acylation reaction of alkyl- and alkoxybenzenes with aliphatic and aromatic carboxylic acids at 250 °C. Bi(NTf2)3 was more effective than Eu(NTf2)3 at lower temperature, but proved to be hydrolyzed in the presence of a small amount of water to give HNTf2 and [Bi6O4(OH)4(H2O)6](NTf2)6. The structure of the latter compound was confirmed by a single crystal X-ray analysis. Among five Br?nsted acids, HOTf, HNTf2, HCTf3, TsOH, and Nafion SAC-13, HNTf2 has proved to be the most efficient catalyst and more effective than Eu(NTf2)3 for the acylation of p-xylene with heptanoic acid at 220 °C or lower temperature. HNTf2 catalyzed the acylation of anisole with carboxylic acids in high yields in refluxing toluene with azeotropic removal of water.

Lewis acid-catalyzed Friedel-Crafts acylation reaction using carboxylic acids as acylating agents

Rare-earth metal Lewis acids, in particular Eu(NTf2) 3, were found to be efficient catalysts for Friedel-Crafts acylation reaction using aliphatic as well as aromatic carboxylic acids as acylating agents at high temperature.