35048-56-7Relevant academic research and scientific papers
Synthesis of N-Lauroyl Sarcosine by Amidocarbonylation: Comparing Homogeneous and Heterogeneous Palladium Catalysts
Hancker, S?ren,Kreft, Stefanie,Neumann, Helfried,Beller, Matthias
supporting information, p. 2045 - 2051 (2017/12/26)
An improved system for the synthesis of N-acyl amino acids via Pd-catalyzed amidocarbonylation is reported. Utilizing inexpensive Pd black gives the industrially important surfactant N-lauroyl sarcosine in excellent yields (95%) on a multi-gram scale. Advantages of the new system include reusability, decreased process temperature, and, importantly, drastically decreased co-catalyst loading.
Novel arylpiperazines as selective α1-adrenergic receptor antagonists
Li, Xiaobing,Murray, William V.,Jolliffe, Linda,Pulito, Virginia
, p. 1093 - 1096 (2007/10/03)
A novel series of arylpiperazines has been synthesized and identified as antagonists of α(1a) adrenergic receptor (α(1a)-AR) implicated in benign prostatic hyperplasia. These compounds selectively bind to membrane bound α(1a)-AR with K(i)s as low as 0.66 nM. As such, these potentially represent a viable treatment for BPH without the side effects associated with known α1-adrenergic antagonists. (C) 2000 Elsevier Science Ltd. All rights reserved.
Syngas reactions XIV. Amidocarbonylation as a route to α-amidocarboxylic acids
Lin, J.J.,Knifton, John F.
, p. 99 - 110 (2007/10/02)
The amidocarbonylation of olefin and aldehyde substrates has been applied to the synthesis of a variety of amidocarboxylic acids, including surface active agents (e.g.C14-C16 N-acyl-α-amino acids), specialty surfactants (such as the sarcosinates), intermediates for sweeteners (e.g. aspartame), food additives (e.g. glutamic acid), and certain chelating agents.Homogeneous cobalt and rhodium-based catalysts, modified, for example, with sulfoxide and bidentate phosphine ligands, have been tailored to the synthesis of each individual class of product.Process studies, including examinations of reaction rate, product selectivity, as well as catalyst stability, have been undertaken for N-acetylglycine and amido acid surfactant syntheses.
