350482-10-9

Upstream product

• 350482-09-6 (1R,2S,4S,5S,6R,7R,8R,9S,10S)-6,9-epoxy-4,5-O-isopropylidenedioxy-4-[[(4R)-2,2-dimethyl-3-(p-toluenesulfonyl)oxazolidin-4-yl]methyl]tetracyclo[6.2.1.0^2,7.0^2,10]undecan-3-one 
• 503-38-8 trichloromethyl chloroformate 

Downstream Products

• 350482-12-1 (1R,4S,4aS,5R,6S,7S,8aS)-5-hydroxy-6,7-O-isopropylidenedioxy-7-[(4S)-2-oxo-3-(p-toluenesulfonyl)oxazolidin-4-yl]methyl-1,4,4a,5,6,7,8,8a-octahydro-endo-1,4-methanonaphthalen-8-one 
• 350482-14-3 (1R,5S,6S)-5,6-O-isopropylidenedioxy-4-oxo-5-[(4S)-2-oxo-3-(p-toluenesulfonyl)oxazolidin-4-yl]methyl-2-cyclohexenyl methansulfonate 
• 350482-15-4 (1R,5S,6S)-5,6-dihydroxy-4-oxo-5-[(4S)-2-oxo-3-(p-toluenesulfonyl)oxazolidin-4-yl]methyl-2-cyclohexenyl methansulfonate 
• 350482-13-2 (4R,5S,6S)-4-hydroxy-5,6-O-isopropylidenedioxy-6-[(4S)-2-oxo-3-(p-toluenesulfonyl)oxazolidin-4-yl]methyl-2-cyclohexen-1-one 
• 350482-11-0 (1S,2S,3S,4R,4aR,5R,6S,7S,8aR)-3,5-epoxy-2-iodo-6,7-O-isopropylidenedioxy-7-[(4S)-2-oxo-3-(p-toluenesulfonyl)oxazolidin-4-yl]methyl-1,2,3,4,4a,5,6,8a-octahydro-endo-1,4-methanonaphthalen-8-one 

Relevant academic research and scientific papers

Studies toward the Total Synthesis of Scyphostatin: First Entry to the Highly Functionalized Cyclohexenone Segment

(matrix presented) The cyclohexenone segment 2 of scyphostatin (1), a potent inhibitor of neutral sphingomyelinase, was synthesized in an enantioselective manner starting from the bromo ether 5 and D-serinal derivative 3. The synthetic method features a c

Enantiocontrolled synthesis of the epoxycyclohexenone moieties of scyphostatin, a potent and specific inhibitor of neutral sphingomyelinase

The epoxycyclohexenone moieties 2 and 3b of scyphostatin (1), a potent and specific inhibitor of neutral sphingomyelinase, were synthesized in enantiomerically pure forms starting from (-)-quinic acid (11). The synthetic method features (i) the preparatio