35050-54-5Relevant academic research and scientific papers
Total Synthesis of (+)-Oxo-tomaymycin
Benedetti, Fran?oise,Perrin, Marc-Antoine,Bosc, Sebastien,Chouteau, Franck,Champion, Nicolas,Bigot, Antony
, p. 762 - 768 (2020)
(+)-Oxo-tomaymycin, a naturally occurring substance of the pyrrolo-1,4-benzodiazepine family, was synthesized using a short and efficient route. The key construction of the seven-membered ring by amide bond formation was realized via a chemoselective Ar-NO2 reduction using TiCl3 under acidic conditions, followed by a spontaneous cyclization. This synthesis was easily scaled up to 80 g, and it should be amenable to the production of larger quantities.
Biosynthesis of [14C]-11-De-O-Methyltomaymycin, a Precursor of Radiolabelled Antibody Drug Conjugates
Aubert, Catherine,Lavisse, Mélanie,Roy, Sebastien
, p. 2424 - 2429 (2021/06/09)
Antibody drug conjugates (ADCs) are one of the most promising technologies to treat cancer as they combine the specificity of an antibody with the high potency of a cytotoxic molecule such as tomaymycin derivatives, which are DNA-interactive antitumor ant
STRUCTURE AND SYNTHESIS OF SEN-215 AND OXOTOMAYMYCIN
Mori, Miwako,Uozumi, Yasuhiro,Ban, Yoshio
, p. 1257 - 1260 (2007/10/02)
The structure of SEN-215 was determined as (11aS)(E)-2-ethylidene-2,3,5,10,11,11a-hexahydro-8-hydroxy-7-methoxy-5-oxo-1H-pyrrolo(2,1-c)(1,4)benzodiazepine by conversion of (E)- and - (Z)- pretomaymycin into (E)- and (Z)- SEN-215.
