350511-12-5 Usage
Uses
Used in Pharmaceutical Research and Development:
5-Bromo-N-2-thiazolyl-2-pyridinamine is used as an intermediate in the synthesis of pharmaceutical compounds and other organic chemicals. Its unique structure and properties make it a valuable building block in medicinal chemistry, allowing for the development of new drugs with improved efficacy and safety profiles.
Used in Medicinal Chemistry:
As a building block in medicinal chemistry, 5-Bromo-N-2-thiazolyl-2-pyridinamine is utilized to create novel compounds with potential biological activities. Its presence in various chemical structures can contribute to the modulation of biological targets, such as enzymes, receptors, and ion channels, which can lead to the discovery of new therapeutic agents.
Used in Organic Chemistry:
In the field of organic chemistry, 5-Bromo-N-2-thiazolyl-2-pyridinamine serves as a versatile intermediate for the synthesis of a wide range of organic compounds. Its reactivity and functional groups enable chemists to perform various chemical reactions, leading to the formation of new molecules with diverse applications in various industries.
Overall, 5-Bromo-N-2-thiazolyl-2-pyridinamine is a significant compound in the fields of pharmaceutical research and development, medicinal chemistry, and organic chemistry due to its unique structure, properties, and potential applications. Its versatility as an intermediate and building block allows for the creation of new compounds with promising biological activities and therapeutic potential.
Check Digit Verification of cas no
The CAS Registry Mumber 350511-12-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,0,5,1 and 1 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 350511-12:
(8*3)+(7*5)+(6*0)+(5*5)+(4*1)+(3*1)+(2*1)+(1*2)=95
95 % 10 = 5
So 350511-12-5 is a valid CAS Registry Number.
350511-12-5Relevant academic research and scientific papers
PYRIDINE DERIVATIVES USEFUL AS GLUCOKINASE ACTIVATORS
-
Page/Page column 58, (2009/05/30)
Novel heterocyclic compounds of the formula (I) in which R1, R2, R3, R4 and D have the meanings indicated in Claim 1, are activators of glucokinase and can be used for the prevention and/o treatment of Diabetes Typ 1 and 2, obesity, neuropathy and/or nephropathy.
Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA
Kim, Soong-Hoon,Tokarski, John S.,Leavitt, Kenneth J.,Fink, Brian E.,Salvati, Mark E.,Moquin, Robert,Obermeier, Mary T.,Trainor, George L.,Vite, Gregory G.,Stadnick, Linda K.,Lippy, Jonathan S.,You, Dan,Lorenzi, Matthew V.,Chen, Ping
, p. 634 - 639 (2008/09/18)
2-Amino-5-(thioaryl)thiazoles are potent inhibitors of TrkA (e.g., 20h, TrkA IC50 = 0.6 nM) that show anti-proliferative effect in cellular assays. A proposed inhibitor binding mode to TrkA active site is consistent with key SAR observations.
Synthesis and biological activity of N-aryl-2-aminothiazoles: Potent pan inhibitors of cyclin-dependent kinases
Misra, Raj N.,Xiao, Hai-Yun,Williams, David K.,Kim, Kyoung S.,Lu, Songfeng,Keller, Kristen A.,Mulheron, Janet G.,Batorsky, Roberta,Tokarski, John S.,Sack, John S.,Kimball, S. David,Lee, Francis Y.,Webster, Kevin R.
, p. 2973 - 2977 (2007/10/03)
N-Aryl aminothiazoles 6-9 were prepared from 2-bromothiazole 5 and found to be CDK inhibitors. In cells they act as potent cytotoxic agents. Selectivity for CDK1, CDK2, and CDK4 was dependent of the nature of the N-aryl group and distinct from the CDK2 se
