350511-12-5Relevant articles and documents
PYRIDINE DERIVATIVES USEFUL AS GLUCOKINASE ACTIVATORS
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Page/Page column 58, (2009/05/30)
Novel heterocyclic compounds of the formula (I) in which R1, R2, R3, R4 and D have the meanings indicated in Claim 1, are activators of glucokinase and can be used for the prevention and/o treatment of Diabetes Typ 1 and 2, obesity, neuropathy and/or nephropathy.
Synthesis and biological activity of N-aryl-2-aminothiazoles: Potent pan inhibitors of cyclin-dependent kinases
Misra, Raj N.,Xiao, Hai-Yun,Williams, David K.,Kim, Kyoung S.,Lu, Songfeng,Keller, Kristen A.,Mulheron, Janet G.,Batorsky, Roberta,Tokarski, John S.,Sack, John S.,Kimball, S. David,Lee, Francis Y.,Webster, Kevin R.
, p. 2973 - 2977 (2007/10/03)
N-Aryl aminothiazoles 6-9 were prepared from 2-bromothiazole 5 and found to be CDK inhibitors. In cells they act as potent cytotoxic agents. Selectivity for CDK1, CDK2, and CDK4 was dependent of the nature of the N-aryl group and distinct from the CDK2 se