350581-71-4Relevant academic research and scientific papers
Simple microwave-assisted ligand-free Suzuki cross-coupling: Functionalization of halo-pyrimidine moieties
Colombo, Matteo,Giglio, Marco,Peretto, Ilaria
, p. 1077 - 1081 (2008/12/20)
(Chemical Equation Presented) An advantageous ligand-free protocol for Suzuki couplings is described. The synthetic procedure entails microwave irradiation for the reduction of the reaction times and the use of silica cartridges for the purification. Dihalo-pyrimidine structures, interesting scaffolds in medicinal chemistry, were chosen as test compounds.
