350597-49-8

Basic information

• Product Name: 5-CHLORO-2-METHYL-NICOTINIC ACID METHYL ESTER
• Synonyms: 5-CHLORO-2-METHYL-NICOTINIC ACID METHYL ESTER;methyl 5-chloro-2-methylnicotinate;3-Pyridinecarboxylic acid, 5-chloro-2-Methyl-, Methyl ester;5-Chloro-2-methylpyridine-3-carboxylic acid methyl ester;methyl 5-chloro-2-methylpyridine-3-carboxylate
• CAS NO: 350597-49-8
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Mol File: 350597-49-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 45-47℃
• Boiling Point: 233.5 °C at 760 mmHg
• Flash Point: 95 °C
• Appearance: /
• Density: 1.248 g/cm³
• Vapor Pressure: 0.0558mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.63±0.20(Predicted)
• CAS DataBase Reference: 5-CHLORO-2-METHYL-NICOTINIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-METHYL-NICOTINIC ACID METHYL ESTER(350597-49-8)
• EPA Substance Registry System: 5-CHLORO-2-METHYL-NICOTINIC ACID METHYL ESTER(350597-49-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 350597-49-8(Hazardous Substances Data)

Usage

General Description

5-CHLORO-2-METHYL-NICOTINIC ACID METHYL ESTER is a chemical compound with the molecular formula C8H8ClNO2. It is a methyl ester derivative of 5-chloro-2-methyl-nicotinic acid, which is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and biologically active compounds. 5-CHLORO-2-METHYL-NICOTINIC ACID METHYL ESTER is a chlorinated derivative of nicotinic acid, a precursor to the coenzymes NAD and NADP, and it has potential applications in the treatment of various diseases such as cancer, inflammation, and neurodegenerative disorders. The chemical and physical properties of 5-CHLORO-2-METHYL-NICOTINIC ACID METHYL ESTER make it a valuable intermediate for the development of new pharmaceuticals and agrochemicals.

InChI:InChI=1/C8H8ClNO2/c1-5-7(8(11)12-2)3-6(9)4-10-5/h3-4H,1-2H3

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 325855-84-3 (2E,4Z)-2-Acetyl-4-chloro-5-dimethylamino-penta-2,4-dienoic acid methyl ester 

Downstream Products

• 917882-51-0 2-[(E/Z)-2-(4-bromophenyl)vinyl]-3-carboxy-5-chloropyridinium chloride 
• 870843-51-9 (5-chloro-2-methylpyridin-3-yl)methanol 
• 1170702-73-4 2-[(E)-2-(4-bromophenyl)vinyl]-5-chloronicotinic acid 
• 766506-30-3 C₁₄H₉BrClNO₂ 
• 917878-65-0 7-bromo-3-chloro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one 
• 917882-66-7 MK-2461 
• 917942-73-5 C₁₄H₉BrClNO₂ 
• 1309960-89-1 N-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(2,4-dimethoxybenzyl)ethenesulfonamide 
• 1309960-90-4 N-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(2,4-dimethoxybenzyl)-2-(1H-imidazol-1-yl)ethanesulfonamide 
• 1309960-77-7 N-methyl-N'-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyrazin-2-ylmethyl)sulfuric diamide 
• 917882-66-7 N-((2R)-1,4-dioxan-2-ylmethyl)-N-methyl-N’-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]sulfamide 
• 917878-68-3 3-chloro-7-[(2,4-dimethoxybenzyl)amino]-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one 

Relevant articles and documents

Process development and large-scale synthesis of a c-Met kinase inhibitor

A highly convergent synthesis of c-Met kinase inhibitor 1 has been demonstrated on a multikilogram scale using three key fragments: dihalotricyclic core 2, chiral sulfamide side chain 3, and pyrazole boronic ester 4. The chirality in sulfamide side chain 3 was installed using the cheap and readily available starting material (S)-epichlorohydrin. A total of 2.71 kg of 1 were isolated in seven steps (the longest linear sequence).

5H-BENZO[4,5]CYCLOHEPTA[1,2-B]PYRIDINE NMDA/NR2B ANTAGONISTS

Benzo [4,5]cyclohepta[1,2-b]pyridines represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.