350672-17-2

Basic information

• Product Name: 2-(chloromethyl)-5-(2-fluorophenyl)-1,3,4-oxadiazole
• Synonyms: 2-(chloromethyl)-5-(2-fluorophenyl)-1,3,4-oxadiazole
• CAS NO: 350672-17-2
• Molecular Formula: C₉H₆ClFN₂O
• Molecular Weight: 212.6081432
• Mol File: 350672-17-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(chloromethyl)-5-(2-fluorophenyl)-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(chloromethyl)-5-(2-fluorophenyl)-1,3,4-oxadiazole(350672-17-2)
• EPA Substance Registry System: 2-(chloromethyl)-5-(2-fluorophenyl)-1,3,4-oxadiazole(350672-17-2)

Safety Data

• Hazardous Substances Data: 350672-17-2(Hazardous Substances Data)

Usage

General Description

2-(chloromethyl)-5-(2-fluorophenyl)-1,3,4-oxadiazole is a chemical compound with the molecular formula C9H6ClFN2O. It is a heterocyclic organic compound with potential applications in pharmaceutical and agrochemical industries. 2-(chloromethyl)-5-(2-fluorophenyl)-1,3,4-oxadiazole contains a chlorine atom and a fluorophenyl group, which makes it a potentially valuable building block in the synthesis of complex organic molecules. Its oxadiazole ring structure also provides unique properties and potential biological activities, making it an interesting target for further research and development in the field of medicinal chemistry and drug discovery.

Upstream product

• 446-24-2 2-fluorobezohydrazide 
• 74974-54-2 2-chloro-1,1,1-trimethoxyethane 
• 499129-06-5 PCM-0102510 
• 443-26-5 2-fluoro-benzoic acid ethyl ester 
• 445-29-4 o-fluoro-benzoic acid 

Relevant articles and documents

Oxazole ring-containing honokiol thioether derivative and preparation method and application thereof

The invention discloses an oxazole ring-containing honokiol thioether derivative, a preparation method thereof and application of the oxazole ring-containing honokiol thioether derivative as an alpha-glucosidase inhibitor, the chemical structure of the oxazole ring-containing honokiol thioether derivative is shown as a general formula (I), and R is selected from non-substituted or substituted phenyl. Compared with the prior art, the invention provides the novel honokiol thioether derivative containing the oxazole ring, and the honokiol thioether derivative containing the oxazole ring has good inhibitory activity on alpha-glucosidase, provides more possibilities for treating diabetes, and is expected to be used for preparing novel candidate drug molecules for treating diabetes. In addition, the preparation process is simple, the cost is low, and the yield is high.

Design and synthesis of new norfloxacin-1,3,4-oxadiazole hybrids as antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)

Toward the search of new antibacterial agents to control methicillin-resistant Staphylococcus aureus (MRSA), a class of new norfloxacin-1,3,4-oxadiazole hybrids were designed and synthesized. Antibacterial activities against drug-sensitive bacteria S. aureus and clinical drug resistant isolates of MRSA were evaluated. Compound 5k exhibited excellent antibacterial activities against S. aureus (MIC: 2 μg/mL) and MRSA1–3 (MIC: 0.25–1 μg/mL). The time-kill kinetics demonstrated that compound 5k had an advantage over commonly used antibiotics vancomycin in killing S. aureus and MRSA. Moreover, compound 5k could inhibit the bacteria and destroy their membranes in a short time, and showed very low cytotoxicity to NRK-52E cells. Some interesting structure-activity relationships (SARs) were also discussed. These results indicated that these norfloxacin-1,3,4-oxadiazole hybrids could be further developed into new antibacterial agents against MRSA.

Synthesis and antifeedant activity of new oxadiazolyl 3(2H)-pyridazinones

A total of 20 new compounds containing the oxadiazolyl 3(2H)-pyridazinone moiety were synthesized. The structures of all the compounds were confirmed by 1H NMR, IR, MS, and elemental analysis. Their insect antifeedant activities against Asiatic corn borer Ostrinia furnacalis (Guenee) were examined and compared with commercial azadirachtin. The compounds exhibited significant levels of activity. The feeding deterrency values of IIIa,j were 57% and 51% at 500 mg/kg concentration, respectively.