350678-35-2

Upstream product

• 350678-31-8 N-((R)-1-Phenyl-ethyl)-N-(2-phenylsulfanyl-ethyl)-formamide 
• 5535-49-9 2-Chloroethyl phenyl sulfide 
• 350678-27-2 ((R)-1-Phenyl-ethyl)-(2-phenylsulfanyl-ethyl)-amine 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Downstream Products

• 350678-43-2 (R)-1-Methyl-4-phenylsulfanyl-3,4-dihydro-1H-isoquinoline-2-carbaldehyde 

Relevant academic research and scientific papers

Determination of ring conformation in 1-benzyl-1,2,3,4- tetrahydroisoquinolines and a new synthesis of the chiral compounds

The conformation of the piperideine ring in 1-benzyl-1,2,3,4- tetrahydroisoquinolines was determined as 2H3 form with a pseudoaxial position of the 1-benzyl group by circular dichroism (CD) spectral comparison with 1-methyl-1,2,3,4-tetrahydroisoquinolines. The chiral center at C-1 of 1,2,3,4-tetrahydroisoquinoline (TIQ) was constructed in an unambiguous manner by applying a new method of TIQ synthesis utilizing the Pummerer reaction as a key step. Enantiomerically pure (R)- and (S)-1-methyl- and 1- benzyltetrahydroisoquinolines (1) were prepared starting from readily available chiral amines (2) in good overall yields.