350795-67-4

Upstream product

• 350796-01-9 ethyl 6-amino-3,4-dihydro-3-oxoquinoxaline-2-carboxylate 
• 4017-32-7 6-chloro-3,4-dihydro-3-oxo-2-quinoxalinecarboxylic acid,ethyl ester 
• 36309-52-1 diethyl N-[(2,4-dinitrophenyl)amino]malonate 
• 103-71-9 phenyl isocyanate 
• 350795-96-9 ethyl (+/-)-6-chloro-1,2,3,4-tetrahydro-3-oxoquinoxaline-2-carboxylate 

Relevant academic research and scientific papers

Synthesis of a set of ethyl 1-carbamoyl-3-oxoquinoxaline-2-carboxylates and of their constrained analogue imidazo[1,5-a]quinoxaline-1,3,4-triones as glycine/NMDA receptor antagonists

The synthesis and glycine/NMDA and AMPA receptor affinities of a set of ethyl (±) 1-N-carbamoyl-1,2,3,4-tetrahydro-3-oxoquinoxaline-2-carboxylates 1-11 and those of their constrained analogue (±) 1,2,3,3a,4,5-hexahydroimidazo[1,5-a]quinoxaline-1,3,4-triones 12-24 are reported. Compounds 1-11 bear a side-chain at position 1 which has been spatially constrained in compounds 12-24. Most of the reported tricyclic derivatives 12-24 showed glycine/NMDA binding activity comparable to that of their corresponding bicyclic analogues 1-11 providing further evidence that the spatial orientation of the side-chain is an important structural requirement for glycine/NMDA receptor antagonists.