350799-70-1Relevant academic research and scientific papers
Transformation of a κ-opioid receptor antagonist to a κ-agonist by transfer of a guanidinium group from the 5′- to 6′-position of naltrindole
Kumar Sharma,Jones,Metzger,Ferguson,Portoghese
, p. 2073 - 2079 (2001)
The importance of the indole scaffold of GNTI 3 in directing its address (5′-guanidinium group) to associate with the Glu297 residue of the κ-opioid receptor was investigated by the synthesis and biological evaluation of its 4′- (4a), 6′- (4b), and 7′- (4
