3508-24-5Relevant articles and documents
Radioactive iodine labeling method
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Paragraph 0084; 0085; 0086; 0087; 0088; 0089; 0090-0111, (2017/07/23)
The invention discloses a radioactive iodine labeling method. Ar-B(OH)2 is allowed to react with NaI in a reaction solvent in the presence of a copper coordination compound so as to obtain Ar-I, so radioactive iodine labeling is realized. The method
Direct n.c.a. electrophilic radioiodination of deactivated arenes with N-chlorosuccinimide
Mennicke,Holschbach,Coenen
, p. 721 - 737 (2007/10/03)
An efficient method for the direct electrophilic no-carrier-added (n.c.a.) radioiodination of deactivated arenes has been developed using N-chlorosuccinimide (NCS)/radioiodide in trifluoromethanesulfonic acid (triflic acid). Optimization of the one pot labelling procedure using chlorobenzene as a model substrate resulted in a radiochemical yield of 75% within 15 min at room temperature. Drying of the aqueous radioiodide solution prior to radiolabelling was not required. Radioiodination of weakly activated and deactivated monosubstituted benzene derivatives gave rise to radiochemical yields of about 80% with an electrophilic substitution pattern. Strongly deactivated aromatic compounds were radioiodinated with high radiochemical yields of about 70% exclusively in their meta-position using a reaction temperature of 75°C and a reaction time of 1 h. With regard to the reaction mechanism, in situ formed radioiodo(I) trifluoromethanesulfonate (triflyl [131I]hypoiodite) is discussed as electrophilic reagent.
Metal salts as in situ oxidants for the n.c.a. radioiodination of weakly activated arenes
Mennicke,Holschbach,Coenen
, p. S294-S296 (2007/10/03)
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