350829-54-8

Basic information

• Product Name: 4-(4-methylphenyl)-1,3-diphenyl-4,5-dihydro-1',3'-dioxospiro[1H-pyrazole-5,2'-indane]
• Synonyms: 4-(4-methylphenyl)-1,3-diphenyl-4,5-dihydro-1',3'-dioxospiro[1H-pyrazole-5,2'-indane]
• CAS NO: 350829-54-8
• Molecular Formula: C30H22N2O2
• Molecular Weight: 442.50788
• Mol File: 350829-54-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-methylphenyl)-1,3-diphenyl-4,5-dihydro-1',3'-dioxospiro[1H-pyrazole-5,2'-indane](CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methylphenyl)-1,3-diphenyl-4,5-dihydro-1',3'-dioxospiro[1H-pyrazole-5,2'-indane](350829-54-8)
• EPA Substance Registry System: 4-(4-methylphenyl)-1,3-diphenyl-4,5-dihydro-1',3'-dioxospiro[1H-pyrazole-5,2'-indane](350829-54-8)

Safety Data

• Hazardous Substances Data: 350829-54-8(Hazardous Substances Data)

Upstream product

• 606-23-5 1H-indene-1,3(2H)-dione 
• 104-87-0 4-methyl-benzaldehyde 
• 15875-51-1 2-(4-methyl-benzylidene)-indan-1,3-dione 
• 15424-14-3 N-phenylbenzohydrazonoyl chloride 

Relevant articles and documents

1,3-Dipolar cycloadditions of arylcarbonitrile oxides and diaryl nitrilimines with some 2-arylmethylene-1,3-indanediones; regiochemistry of the reactions

Ring-closure reaction affording spiroisoxazolines and spiropyrazolines via a 1,3-dipolar cycloaddition between the title compounds, occurs with high regioselectivity.

Simple Regioselective Synthesis of Spiro[2H-indene-2,3'-[3H]pyrazoles]

1,3-Dipolar cycloaddition reaction of nitrilimines to a variety of 2-arylmethylidene-1-indanones 1 or 2-arylmethylidene-1,3-indandiones 5 gave the corresponding spiro[2H-indene-2,3'-[3H]pyrazol]-1(3H)-one 3 and their 1,3-dione derivatives 6 in high regioselectivity. The stereo-configuration of 3 (3'R, 4'S or its enantiomeric form) was established by nOe-difference technique as well as single crystal X-ray diffraction analysis.