35094-87-2

Basic information

• Product Name: 2,4,5-TRIHYDROXYBENZALDEHYDE
• Synonyms: 2,4,5-TRIHYDROXYBENZALDEHYDE;2,4,5-Trihydroxybenzaldehyde,99%;2,4,5-Trihydroxybenzaldehyde, 99% 1GR;5-Formylbenzene-1,2,4-triol;2,4,5-Trihydroxybenzaldehyde 99%
• CAS NO: 35094-87-2
• Molecular Formula: C₇H₆O₄
• Molecular Weight: 154.12
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Aldehydes;C7;Carbonyl Compounds;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 35094-87-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 223-225 °C(lit.)
• Boiling Point: 237.46°C (rough estimate)
• Flash Point: 196.8 °C
• Appearance: Yellow to brown or khaki/Crystalline Powder
• Density: 1.3725 (rough estimate)
• Vapor Pressure: 2.89E-06mmHg at 25°C
• Refractive Index: 1.6400 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 7.41±0.23(Predicted)
• Sensitive: Air Sensitive
• BRN: 2250084
• CAS DataBase Reference: 2,4,5-TRIHYDROXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-TRIHYDROXYBENZALDEHYDE(35094-87-2)
• EPA Substance Registry System: 2,4,5-TRIHYDROXYBENZALDEHYDE(35094-87-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 35094-87-2(Hazardous Substances Data)

Usage

Chemical Properties

yellow to brown or khaki crystalline powder

Uses

Different sources of media describe the Uses of 35094-87-2 differently. You can refer to the following data:
1. 2,4,5-Trihydroxybenzaldehyde is a useful reactant for the preparation of bis-?indolylmethanes as a potential for β-?glucuronidase inhibitors.
2. 2,4,5-Trihydroxybenzaldehyde may be used in the synthesis of:2,4,5-tribenzyloxybenzaldehyde2,4,5-trihydroxybenzaldehyde N-(diphenylmethylene)hydrazine2-hydroxy-4,5-dimethoxybenzaldehyde

General Description

2,4,5-Trihydroxybenzaldehyde (2,4,5-THBA) is a tri-substituted benzaldehyde that can be prepared from sesamol. Its free radical-quenching ability, antioxidant bioactivity and cytotoxicity have been assessed. 2,4,5-THBA has been identified as one of the components in the ethyl acetate extract of Beta vulgaris var. cicla seeds. The freezing point, boiling point, density and refractive index of 2,4,5-THBA are 499.65K, 510.61K, 1.3725g/cm3 and 1.6400, respectively.

InChI:InChI=1/C7H6O4/c8-3-4-1-6(10)7(11)2-5(4)9/h1-3,9-11H

Upstream product

• 5780-00-7 2-methoxy-4,5-methylenedioxybenzaldehyde 
• 533-73-3 1,2,4-Trihydroxybenzene 
• 122-51-0 orthoformic acid triethyl ester 
• 106-51-4 p-benzoquinone 
• 621-59-0 isovanillin 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 29865-97-2 2,5-dihydroxy-4-methoxy-benzaldehyde 
• 77-78-1 dimethyl sulfate 
• 135-77-3 1,2,4-trimethoxy-benzene 
• 68-12-2 N,N-dimethyl-formamide 
• 74-90-8 hydrogen cyanide 

Downstream Products

• 207743-58-6 2,3,6,8-tetrahydroxybenzofuro[3,2-b][1]benzopyrylium chloride 

Relevant articles and documents

Cytotoxicity effects of di- and tri-hydroxybenzaldehydes as a chemopreventive potential agent on tumor cells

As part of our earlier search for new compounds with improved biological activities including antioxidant, anti-inflammatory, and tumor growth inhibition activities, we synthesized 2,4,5-trihydroxybenzaldehyde (2,4,5-THBA) from commercially available Sesa

Synthesis and biological evaluation of 2-aroylbenzofurans, rugchalcones A, B and their derivatives as potent anti-inflammatory agents

An efficient synthesis of 2-aroylbenzofurans, rugchalcones A, B and their derivatives was accomplished in excellent yields by the Rap–Stoermer reaction between substituted salicylaldehydes and phenacyl bromides. Later their anti-inflammatory effects were evaluated in lipopolysaccharide (LPS)-induced RAW-264.7 macrophages. The compounds were exhibited exceptional potency against inflammatory mediated NO production with no cytotoxicity at 10?μM concentration and IC50values are found in the range from 0.75 to 13.27?μM. Among the 2-aroylbenzofurans prepared in this study, compounds 4 (99.6%; IC50?=?0.57), rugchalcone B (2) (99.3%; IC50?=?4.13), 7 (96.8%; IC50?=?1.90) and 8 (74.3%; IC50?=?0.99) were showed the maximum inhibitory activity. This study suggests that compounds 2, 4, 7 and 8 which are having 4-hydroxyphenyl group and/or hydroxy (–OH) group at 5- and/or 6-position of benzofuran motif could be considered as a promising scaffolds for the further development of iNOS inhibitors for potential anti-inflammatory applications.