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7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-benzooxazol-2-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

350992-10-8

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350992-10-8 Usage

Uses

Acute schizophrenia.

Check Digit Verification of cas no

The CAS Registry Mumber 350992-10-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,0,9,9 and 2 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 350992-10:
(8*3)+(7*5)+(6*0)+(5*9)+(4*9)+(3*2)+(2*1)+(1*0)=148
148 % 10 = 8
So 350992-10-8 is a valid CAS Registry Number.
InChI:InChI=1/C24H23N3O2/c28-24-25-21-10-5-11-22(23(21)29-24)27-14-12-26(13-15-27)17-18-6-4-9-20(16-18)19-7-2-1-3-8-19/h1-11,16H,12-15,17H2,(H,25,28)

350992-10-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-1,3-benzoxazol-2-one

1.2 Other means of identification

Product number -
Other names Bifeprunox [INN]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:350992-10-8 SDS

350992-10-8Downstream Products

350992-10-8Relevant academic research and scientific papers

New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D2-receptor and serotonin 5-HT1A-receptor affinities

Feenstra, Rolf W,De Moes, Janpeter,Hofma, Jos J,Kling, Henk,Kuipers, Wilma,Long, Stephen K,Tulp, Martin Th.M,Van der Heyden, Jan A.M,Kruse, Chris G

, p. 2345 - 2349 (2001)

This paper describes the syntheses of several 1-aryl-4-(biarylmethylene)piperazines and the results of the determination of their affinity for D2 and 5-HT1A receptors. A selection of these compounds was evaluated in vivo, resulting in the identification of a drug candidate which is being clinically evaluated as a potential atypical antipsychotic with reduced extrapyrimidal side effects.

Improved synthesis of antipsychotic drug bifeprunox

Laus, Gerhard,Nerdinger, Sven,Kahlenberg, Volker,Schottenberger, Herwig

, p. 1655 - 1660 (2016/11/06)

A new and efficient six-step synthesis of the antipsychotic drug bifeprunox is reported. The key step is azidation of a lithiated phenol ether. Subsequent reduction of the azide, removal of phenol protecting group, and cyclization lead to the desired benzoxazolinone.

3H-BENZOOXAZOL-2-ONE MODULATORS OF D2 RECEPTOR AND/OR 5-HT1A RECEPTOR

-

Page/Page column 18, (2010/06/11)

The present invention relates to new 3H-benzooxazol-2-one modulators of D2 receptors and/or 5-HT1A receptors, pharmaceutical compositions thereof, and methods of use thereof.

Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same

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Page/Page column 7, (2008/06/13)

The present disclosure provides novel pharmaceutical compounds and methods for making the same, novel pharmaceutical dosage forms and methods for making the same, and methods for using said compounds and dosage forms to treat and prevent diseases and/or d

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