351-16-6Relevant academic research and scientific papers
Synthesis, spectroscopic characterization, X-ray crystal structure, antimicrobial, DNA-binding, alkaline phosphatase and insulin-mimetic studies of oxidovanadium(IV) complexes of azomethine precursors
Munawar, Khurram Shahzad,Ali, Saqib,Tahir, Muhammad Nawaz,Khalid, Nasir,Abbas, Qamar,Qureshi, Irfan Zia,Hussain, Shabbir,Ashfaq, Muhammad
, p. 2275 - 2300 (2020/09/07)
A series of novel azomethine precursors were synthesized by the condensation reactions of 3-(trifluoromethyl)benzenamine (tfmb) with 2-hydroxybenzaldehyde (HL1) (tfmbs), 2,3-dihydroxybenzaldehyde (HL2) (tfmbdh), 2-hydroxy-1-naphthaldehyde (HL3) (tfmbnd) and 5-chloro-2-hydroxybenzaldehyde (HL4) (tfmbCl). The oxidovanadium(IV) complexes of the type [VO(tfmbs)2] (1), [VO(tfmbdh)2] (2), [VO(tfmbnd)2] (3) and [VO(tfmbCl)2] (4) were also prepared by the reaction of ligands HL1–HL4 with vanadyl(V) isopropoxide [VO(OCHMe2)3]. The synthesized compounds were characterized by elemental analysis, FT-IR, multinuclear (1H and 13C) NMR spectroscopies, magnetic susceptibility measurements and thermogravimetry. The studies revealed that binding of precursors with metal took place through azomethine nitrogen and phenolic oxygen. The single-crystal analysis of HL1, HL4 and 3 has been carried out. The intercalation mode of interaction of the complexes with Salmon sperm DNA (SS-DNA) was established by the observed hypochromicity through UV–vis spectroscopic studies. The determined negative ΔG values confirmed the spontaneity of the binding process of complexes with SS-DNA. All the synthesized precursors and complexes were screened for their alkaline phosphatase inhibition, antimicrobial, hemolytic and insulin-mimetic properties, which exhibited significant activities with a few exceptions.
Design, synthesis, docking and in vitro antibacterial study of fluoro substituted schiff bases
Hameed, Kehkashan,Gilani, Syeda Rubina,Raheel, Ahmad,Taj, Babar,Iftikhar, Syed Hussan,Imtiaz-Ud-Din,Sadiqa, Ayesha,Aslam, Ambreen
, p. 782 - 791 (2018/07/15)
Five new fluoro-substituted imines were synthesized by the reaction of different aldehydes with fluoro-substituted anilines. The synthesized compounds were characterized by elemental (CHN) analysis, FT-IR and multinuclear (1H and 13C
PdCl2(Ph3P)2/Salicylaldimine Catalyzed Diarylation of Anilines with Unactivated Aryl Chlorides
Tao, Xiaochun,Li, Lei,Zhou, Yu,Qian, Xuanying,Zhao, Min,Cai, Liangzhen,Xie, Xiaomin
, p. 1749 - 1754 (2017/10/06)
Triphenylphosphine and salicylaldimine could be used as a mixed ligand system to obtain a high catalytic activity for palladium catalyzed diarylation of primary anilines with unactivated aryl chlorides by the synergistic effect of ligands. The activity and selectivity of the catalytic system could be improved by modifying the structure of salicylaldimine. In refluxing o-xylene, PdCl2(Ph3P)2 with 2,5-ditrifluoromethyl N-phenylsalicylaldimine as a coligand shows high efficiency for the diarylation of various anilines. The catalytic system shows good toleration for the steric hindrance of the substrates. The facile catalytic system works as well on the multiple arylation of 1,1′-biphenyl- 4,4′-diamine with aryl chlorides to afford N,N,N′,N′-tetraaryl-1,1′-biphenyl-4,4′-diamines which are important intermediates of organic light emitting diode (OLED) hole transport materials.
