351003-58-2Relevant academic research and scientific papers
Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2 H -1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2 H -1,2,4-benzot
Francotte, Pierre,N?rholm, Ann-Beth,Deva, Taru,Olsen, Lars,Frydenvang, Karla,Goffin, Eric,Fraikin, Pierre,De Tullio, Pascal,Challal, Sylvie,Thomas, Jean-Yves,Iop, Fabrice,Louis, Caroline,Botez-Pop, Iuliana,Lestage, Pierre,Danober, Laurence,Kastrup, Jette S.,Pirotte, Bernard
, p. 9539 - 9553 (2015/01/09)
Two 4-ethyl-substituted pyridothiadiazine dioxides belonging to α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor positive allosteric modulators were cocrystallized with the GluA2 ligand binding domain in order to decipher the impact of
Cycloalkylated benzothiadiazines, a process for their preparation and pharmaceutical compostions containing them
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Page/Page column 8, (2010/02/17)
Compounds of formula (I): wherein: RCy represents an unsubstituted or substituted cycloalkyl group or cycloalkylalkyl group,R1, R2, R3 and R4, which may be the same or different, each represent a hydrogen or halogen atom or a nitro group; a cyano group; a hydroxy group; an alkoxy group; an alkyl group; an unsubstituted or substituted amino group; a carboxy group; an alkoxycarbonyl group; an aryloxycarbonyl group; an unsubstituted or substituted aminocarbonyl group. Medicinal products containing the same which are useful in treating or preventing conditions treatable by an AMPA receptor modulator.
